Objective To explore the relationship between patient-reported outcomes (PRO) and clinical objective indicators in stroke patients. Methods One hundred inpatients diagnosed with stroke and received treatment in Department of Neurology, First Affiliated Hospital of Kunming Medical University from May 2010 to March 2011 were selected as the subjects, and SF-36 Scale was used to measure their PRO. The clinical objective indicators measured on the second day after admission were collected from the medical records, including albumin, globulin, urea, fasting blood glucose, blood potassium, platelet count, activated partial thromboplastin time, and degree of education. The correlation between PRO and clinical objective indicators was analyzed by simple correlation and canonical correlation. Results Simple correlation analysis showed that globulin was negatively correlated with bodily pain (BP) , vitality (VT) (P<0.05) ; urea was negatively correlated with physical functioning (PF) (P<0.05) ; fasting blood glucose was negatively correlated with general health perceptions (GH) (P<0.05) ; blood potassium was negatively correlated with PF (P<0.05) ; platelet count was negatively correlated with PF (P<0.05) ; educational level was positively correlated with PF,BP, VT, and emotional role functioning (RE) (P<0.05) . Canonical correlation analysis showed that canonical variables (μ1, ν1), (μ2, ν2) existed correlation (r=0.536 0, r=0.325 6, P<0.05) . Canonical variable coefficient of globulin and μ1was -0.832 2, canonical variable coefficient of activated partial thromboplastin time and μ1was 0.358 5;canonical variable coefficient of platelet count and μ2was 0.581 6, canonical variable coefficient of educational level and μ2was 0.672 0; canonical variable coefficient of VT and ν1was 1.061 7, canonical variable coefficient of mental health (MH) and ν1 was -0.761 8, canonical variable coefficient of PF and ν2was -0.950 1, canonical variable coefficient of GH and ν2was 0.443 8. Globulin was highly negatively correlated with μ1(r=-0.835 0, P<0.05). PF was highly negatively correlated with ν2(r=-0.738 6, P<0.05) . VT was highly positively correlated with ν1(r=0.727 2, P<0.05) . Conclusion Clinical objective indicators correlate with PROs in stroke patients. Therefore, taking interventions based on the values of these indicators is of some significance in improving the PROs of these patients.%目的 探讨脑卒中患者报告结局(PRO)与临床客观指标的相关性.方法 选取2010年5月—2011年3月在昆明医科大学第一附属医院神经内科确诊住院的100例脑卒中患者,采用健康调查量表(SF-36)对其进行调查并计分,临床客观指标采集于患者住院病历,包括入院第2天清蛋白、球蛋白、尿素、空腹血糖、血钾、血小板计数、活化部分凝血活酶时间及患者文化程度.采用简单相关和典型相关分析对PRO和临床客观指标进行分析并探讨其相关性.结果 简单相关分析结果显示,球蛋白与肌体疼痛(BP)、生命力(VT)呈负相关(P<0.05),尿素与躯体功能(PF)呈负相关(P<0.05),空腹血糖与一般健康状况(GH)呈负相关(P<0.05),血钾与PF呈负相关(P<0.05),血小板计数与PF呈负相关(P<0.05),文化程度与PF、BP、VT、情感角色(RE)呈正相关(P<0.05).典型相关分析显示,典型变量(μ1,ν1)、(μ2,ν2)存在相关性(r=0.5360、0.3256,P<0.05).球蛋白与μ1的典型变量系数为-0.8322,活化部分凝血活酶时间与μ1的典型变量系数为0.3585;血小板计数与μ2的典型变量系数为0.5816,文化程度与μ2的典型变量系数为0.6720;VT与ν1的典型变量系数为1.0617,心理健康(MH)与ν1的典型变量系数为-0.7618;PF与ν2的典型变量系数为-0.9501,GH与ν2的典型变量系数为0.4438.球蛋白与μ1呈高度负相关(r=-0.8350,P<0.05),PF与ν2呈高度负相关(r=-0.7386,P<0.05),VT与ν1呈高度正相关(r=0.7272,P<0.05).结论 PRO与临床客观指标之间存在相关性,关注相关指标并提出相应对策对改善脑卒中患者PRO有一定的价值.
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