Objective To investigate the influence of therapy combined with mirtazapine on the neuropsychological status and clinical symptoms of patients with chronic alcoholism peripheral neuropathy(CAPN). Methods A total of 80 CAPN patients who received treatment in the First Hospital of Wuhan from January 2010 to May 2015 were enrolled. Using random number table method,we divided these patients into control group(n = 40)and observation group(n = 40). Both groups were administrated with conventional treatment,and observation group was also administrated with mirtazapine. Comparison was made between the two groups in the scores of HAMD,HAMA,SCL-90,NIS-LL and NSS,and adverse reactions were recorded during treatment. Results A total of 76 finished 8 _ week treatment,including 39 patients in control group and 37 patients in observation group. Before treatment,the two groups were not significantly different in the scores of HAMD,HAMA and the total score,the total average score and the scores of three subscales of SCL-90( P > 0. 05);8 weeks after treatment,observation group was lower than control group in the scores of HAMD,HAMA and the total score,the total average score and the scores of three subscales of SCL-90(P < 0. 05). Before treatment,the two groups were not significantly different in the scores of NIS-LL and NSS(P > 0. 05);8 weeks after treatment,observation group was lower than control group in the scores of NIS-LL and NSS (P < 0. 05). Before treatment,the two groups were not significantly different in the MCV and SCV in median nerve,ulnar nerve,nervus peroneus communis and tibial nerve(P > 0. 05). 8 weeks after treatment,the two groups were not significantly different in the MCV of median nerve and nervus peroneus communis and the SCV of median nerve(P > 0. 05);observation group was higher than control group in the MCV of ulnar nerve and tibial nerve and was higher than control group in the SCV of ulnar nerve,nervus peroneus communis and tibial nerve(P < 0. 05). No severe adverse reactions occurred in patients during treatment. Conclusion Therapy combined with mirtazapine can effectively improve the neuropsychological status and clinical symptoms of CAPN patients and improve nerve conduction function. We recommend the promotion and usage of therapy combined with mirtazapine in clinical practice.%目的：探讨米氮平联合治疗对慢性酒精中毒性周围神经病（CAPN）患者神经心理状态及临床症状的影响。方法选取2010年1月—2015年5月在武汉市第一医院就诊的 CAPN 患者80例。采用随机数字表法，将其分为对照组和观察组各40例。对照组患者采用常规治疗，观察组患者在常规治疗的基础上联合使用米氮平治疗。比较两组患者治疗前、治疗8周后的汉密尔顿抑郁量表（HAMD）得分、汉密尔顿焦虑量表（HAMA）得分、90项症状自评量表（SCL-90）得分、下肢神经损害量表（NIS-LL）得分、神经症状改变量表（NSS）得分，同时记录两组患者治疗期间的不良反应发生情况。结果共76例患者按要求完成了8周治疗，其中对照组39例，观察组37例。治疗前，两组患者 HAMD、HAMA 得分以及SCL-90的总分、总均分、3个分量表得分比较，差异无统计学意义（P >0.05）；治疗8周后，观察组患者的 HAMD、HAMA 得分以及SCL-90的总分、总均分、3个分量表得分均低于对照组，差异有统计学意义（P <0.05）。治疗前，两组患者NIS-LL、NSS 得分比较，差异无统计学意义（P >0.05）；治疗8周后，观察组患者的NIS-LL、NSS 得分低于对照组，差异有统计学意义（P <0.05）。治疗前，两组患者正中神经、尺神经、腓总神经、胫神经运动神经传导速度（MCV）、感觉神经传导速度（SCV）比较，差异无统计学意义（ P >0.05）。治疗8周后，两组患者正中神经、腓总神经 MCV，正中神经 SCV 比较，差异无统计学意义（ P >0.05）；观察组患者尺神经、胫神经 MCV 高于对照组，尺神经、腓总神经、胫神经 SCV 高于对照组，差异有统计学意义（P <0.05）。两组患者治疗期间均无严重不良反应事件发生。结论米氮平联合治疗可以改善 CAPN 患者的神经心理状态和临床症状，提高患者神经传导功能，建议在临床上推广使用。
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