• 主题
高级搜索  >
历史搜索 清空历史
首页> 中文期刊> 《中国全科医学》 >维吾尔族和汉族高血压伴阻塞性睡眠呼吸暂停低通气综合征患者肾功能比较及影响因素研究

维吾尔族和汉族高血压伴阻塞性睡眠呼吸暂停低通气综合征患者肾功能比较及影响因素研究

页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective To compare the renal function of patients with hypertension combined with obstructive sleep apnea hypopnea syndrome(OSAHS)between Uygur and Han people and the influencing factors. Methods From January 2011 to January 2015,we enrolled 619 patients who received treatment in the First Affiliated Hospital of Xinjiang Medical University, and among them,there were 435 Han people and 184 Uygur people. According to OSAHS grading criteria,we divided Uygur and Han people respectively into mild group〔5 times/ h≤AHI < 15 times/ h〕,medium group(15 times/ h ≤AHI < 30 times/ h) and severe group( AHI ≥30 times/ h). General data and indexes of renal function of each group were collected,and the differences between the two ethnic groups were analyzed. Multivariate Logistic regression analysis was conducted to investigate the influencing factors for renal function. Results Uygur patients and Han patients were significantly different in BMI,FPG, HbA1c ,TC and TG(P < 0. 05),but were not significantly different in gender,average age,smoking,alcohol consumption, length of hypertension,LDL-C,HDL-C,24 hSBP,24 hDBP,AHI and LSaO2 ( P > 0. 05). Patients of different OSAHS grades were significantly different in gender,average age,smoking,length of hypertension,BMI,FPG,HDL-C,24 hSBP, AHI and LSaO2 ( P < 0. 05),but were not significantly different in alcoholic consumption,HbA1c ,TC,TG,LDL-C and 24 hDBP(P > 0. 05). Ethnic groups and OSAHS grades had no interaction(P > 0. 05). Uygur patients and Han patients were significantly different in the levels of serum uric acid and Cyst C(P < 0. 05),but were not significantly different in serum blood urea,SCr,eGFR,24 hUTP and 24 h urine micro albumin levels( P > 0. 05). Patients of different OSAHS grades were significantly different in serum SCr,uric acid,eGFR,24 hUTP and 24 h urine micro albumin level and Cyst C level( P <0. 01),but were not significantly different in the level of serum blood urea(P > 0. 05). Ethnic groups and OSAHS grades had no interaction(P > 0. 05). Multivariate Logistic regression analysis showed that age and length of hypertension had significant influence on eGFR(P < 0. 05);gender,BMI,24 hDBP and LSaO2 had significant influence on 24 hUTP(P < 0. 05);BMI, TC and 24 hSBP had significant influence on 24 h urine micro albumin level(P < 0. 05);ethnic group,gender,age,BMI, HDL-C,24 hSBP and AHI had significant influence on Cyst C(P < 0. 05). Conclusion With the aggregation of OSAHS,the renal function damage of hypertension patients increases,and early renal function damage of Uygur patients is severer. Ethnic group,gender,age,length of hypertension,BMI,blood lipid,blood pressure,AHI and LSaO2 are influencing factors for the indexes of renal function damage.%目的：比较维吾尔族和汉族高血压伴阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的肾功能，并探讨其影响因素。方法选取2011年1月—2015年1月到新疆医科大学第一附属医院就诊的高血压合并 OSAHS 患者619例，其中汉族435例，维吾尔族184例。根据 OSAHS 分度标准，将两族患者分别分为轻〔5次/ h≤睡眠暂停低通气指数（AHI）<15次/ h〕、中（15次/ h≤AHI <30次/ h）、重（AHI≥30次/ h）度3组。收集各组患者的一般资料和肾功能指标，并分析其在不同民族患者间的差异性；采用多因素 Logistic 回归分析探讨各肾功能损害指标的影响因素。结果不同民族患者的 BMI、空腹血糖（FPG）、糖化血红蛋白（HbA1c ）、总胆固醇（TC）及三酰甘油（TG）比较，差异有统计学意义（ P <0.05）；性别、平均年龄、吸烟情况、饮酒情况、高血压病程、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、24 h 平均收缩压（24 hSBP）、24 h 平均舒张压（24 hDBP）、AHI 及最低血氧饱和度（LSaO2）比较，差异无统计学意义（P >0.05）。不同 OSAHS 分度患者的性别、平均年龄、吸烟情况、高血压病程、BMI、FPG、HDL-C、24 hSBP、AHI 及 LSaO2比较，差异有统计学意义（ P <0.05）；饮酒情况、HbA1c、TC、TG、LDL-C及24 hDBP 比较，差异无统计学意义（P >0.05）。民族与 OSAHS 分度间无交互作用（P >0.05）。不同民族患者的尿酸、血清胱抑素（Cyst C）水平比较，差异有统计学意义（P <0.05）；尿素、血肌酐（SCr）、肾小球滤过率估计值（eGFR）、24 h 尿蛋白（24 h UTP）、24 h 尿微量清蛋白水平比较，差异无统计学意义（P >0.05）。不同 OSAHS 分度患者的血清 SCr、尿酸、eGFR、24 hUTP、24 h 尿微量清蛋白、Cyst C 水平比较，差异有统计学意义（P<0.01）；尿素水平比较，差异无统计学意义（ P >0.05）。民族与 OSAHS 分度间无交互作用（ P >0.05）。多因素Logistic 回归分析结果显示，年龄、高血压病程对 eGFR 的影响有统计学意义（ P <0.05）；性别、BMI、24 hDBP、LSaO2对24 hUTP 的影响有统计学意义（P <0.05）；BMI、TC、24 hSBP 对24 h 尿微量清蛋白的影响有统计学意义（P<0.05）；民族、性别、年龄、BMI、HDL-C、24 hSBP、AHI 对血清 Cyst C 水平的影响有统计学意义（ P <0.05）。结论随着 OSAHS 程度的加重，高血压患者的肾功能损害增加，且维吾尔族患者的早期肾功能损害较严重。民族、性别、年龄、高血压病程、BMI、血脂和血压控制情况、AHI 及 LSaO2是肾功能损害指标的影响因素。

著录项

相似文献

  • 中文文献
  • 外文文献
  • 专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号