Objective To investigate the relationship between serum 25 - hydrocyvitamin D〔25 - (OH)VD〕evel and occurrence of metabolic syndrome(MS)in elderly women. Methods 188 elderly post - menopausal female patients(60 -94 years old)who were admitted to the department of geriatrics of Peking University People's Hospital from September 2011 to November 2013,were selected as study subjects. 79 cases with MS were included in MS group,109 without MS were included in non - MS group. According to the median serum 25 - ( OH) VD level(31. 5 nmol/ L),94 cases were included in < 31. 5 nmol/ L group,94 cases were included in ≥31. 5 nmol/ L group. Blood pressure,body weight,body height,body mass index (BMI)were measured and calculated. Serum levels of fasting plasma glucose( FPG),total cholesterol( TC),triglycerides (TG),low - density lipoprotein cholesterol( LDL - C),high - density lipoprotein cholesterol( HDL - C),glycosylated hemoglobin(HbA1c ),serum fasting insulin(FINS),calcium(Ca),phosphorus(P),25 - (OH) VD,bone - specific alkaline phosphatase( BAP)and tartaric - resistant phosphatase( TRAP)were measured. The degree of 25 - (OH)VD deficiency was compared between MS group and non - MS group,the correlation between serum level of 25 - (OH)VD and observation indicators was analyzed. Results There were significant differences in duration of hypertension and diabetes,levels of TG,HDL - C,FPG,HbA1c ,FINS and HOMA - IR between MS group and non - MS group(P < 0. 05). Serum level of 25 - (OH)VD in MS group was significantly lower than that in non - MS group(P < 0. 05). There were significant differences in duration of hyperlipidemia,levels of TG,HDL - C,FPG,HbA1c ,FINS and HOMA - IR between < 31. 5 nmol/ L group and ≥31. 5 nmol/ L group(P < 0. 05). Serum level of 25 - (OH)VD in ≥31. 5 nmol/ L group was significantly higher than that in < 31. 5 nmol/ L group(P < 0. 05). There was significant difference in degree of 25 - (OH)VD deficiency between MS group and non - MS group(P < 0. 05). Serum level of 25 - (OH)VD was negatively correlated with level of TG,FPG and HOMA - IR,respectively,but was positively correlated with level of HDL - C( P < 0. 05). Conclusion Serum level of 25 - (OH)VD is relatively low in elderly women and is related to levels of blood lipid and FPG.%目的：探讨老年女性患者25-羟维生素D〔25-（OH）VD〕水平与代谢综合征（MS）发生发展的相关性。方法收集2011年9月—2013年11月于北京大学人民医院老年科住院的老年女性患者188例，年龄60~94岁，均为绝经后。按照有无 MS 将患者分为 MS 组（79例）和非 MS 组（109例）；按照血清25-（OH）VD中位数（31.5 nmol/ L）将患者分为＜31.5 nmol/ L 组（94例）和≥31.5 nmol/ L 组（94例）。测量血压、身高、体质量、计算体质指数（BMI），并检测空腹血糖（FPG）、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL - C）、高密度脂蛋白胆固醇（ HDL - C）、糖化血红蛋白（ HbA1c ）、空腹胰岛素（ FINS）、血钙（ Ca）、血磷（ P）、血清25-（OH）VD、骨特异性碱性磷酸酶（ BAP）和 抗 酒 石 酸 酸 性 磷 酸 酶（ TRAP）水平，计算胰岛素抵抗指数（HOMA - IR）；比较 MS 组与非 MS 组血清25-（OH）VD缺乏程度；分析血清25-（OH）VD与观察指标的相关性。结果 MS 组高血压病程、糖尿病病程、TG、HDL - C、FPG、HbA1c、FINS、HOMA - IR与非 MS 组比较，差异有统计学意义（P ＜0.05）。MS 组患者血清25-（OH）VD水平低于非 MS 组（P ＜0.05）。＜31.5 nmol/ L 组高血脂病程、TG、HDL - C、FPG、HbA1c、FINS、HOMA - IR与≥31.5 nmol/ L 组比较，差异有统计学意义（ P ＜0.05）。≥31.5 nmol/ L 组患者血清25-（OH）VD水平高于＜31.5 nmol/ L 组（P ＜0.05）。MS 组与非 MS 组血清25-（OH）VD缺乏程度比较，差异有统计学意义（P ＜0.05）。血清25-（OH）VD水平与 TG、FPG、HOMA - IR呈负相关，与 HDL - C呈正相关（P ＜0.05）。结论老年女性患者血清25-（OH）VD水平较低，且与血脂、血糖相关，为临床进一步研究提供了参考依据。
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