Objective To evaluate the efficacy of spleen strengthening and phlegm eliminating therapy combined with caloric restriction on obesity-related polycystic ovary syndrome ( PCOS ) . Methods We enrolled 40 patients with obesity -related PCOS who received treatment in the outpatient gynaecologic Department of Traditional Chinese Medicine of the First Affiliated Hospital of Sun Yat-Sen University from January 2012 to January 2014. The subjects were divided into control group and combined therapy group, with 20 subjects in each group. The control group was orally administrated with diformin tablet, and combined therapy group was administrated with spleen strengthening and phlegm eliminating therapy combined with caloric restriction, with a treatment course of three months for both of the two groups. Comparison was made between the two groups in the indexes of obesity, metabolism and internal secretion and efficacy before and after treatment. Results The two groups were not significantly different (P>0. 05) before treatment and were significantly different (P<0. 05) after treatment in BMI and waist-hip ratio. Before and after treatment, the two groups were not significantly different (P>0. 05) in FPG, HbA1c, TC, TG, HDL-C, LDL-C, fasting insulin and HOMA-IR; while FPG, HbA1c , TC, TG, HDL-C, LDL-C, fasting insulin and HOMA-IR of the two groups after treatment were significantly different (P<0. 05) from those before treatment. The two groups were not significantly different (H =4. 05, P >0. 05) in efficacy. Conclusion Spleen strengthening and phlegm eliminating therapy combined with caloric restriction and oral administration of diformin tablet have similar efficacy on obesity-related PCOS, while spleen strengthening and phlegm eliminating therapy combined with caloric restriction is more effective in improving the indexes about obesity.%目的：了解健脾化痰方联合热量控制对肥胖型多囊卵巢综合征( PCOS)患者的治疗效果。方法选取2012年1月—2014年1月在中山大学附属第一医院中医妇科门诊部就诊的肥胖型PCOS患者40例。随机将其分为对照组和联合治疗组各20例,对照组口服二甲双胍片治疗,联合治疗组采用健脾化痰方联合热量控制治疗,疗程均为3个月。比较两组患者治疗前后的肥胖指标、代谢和内分泌指标及疗效。结果治疗前两组BMI和腰臀比比较,差异无统计学意义(P>0．05)；治疗后两组BMI和腰臀比比较,差异有统计学意义(P<0．05)。治疗前和治疗后,两组空腹血糖( FPG)、糖化血红蛋白( HbA1c )、总胆固醇( TC)、三酰甘油( TG)、高密度脂蛋白胆固醇( HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素、胰岛素抵抗指数(HOMA-IR)比较,差异均无统计学意义(P>0．05)；但治疗后,两组FPG、 HbA1c、 TC、 TG、 HDL-C、 LDL-C、空腹胰岛素及HOMA-IR与治疗前比较,差异均有统计学意义(P<0．05)。两组疗效比较,差异无统计学意义(H=4．50, P>0．05)。结论健脾化痰方联合热量控制与口服二甲双胍片对肥胖型PCOS患者的治疗效果相同,但健脾化痰方联合热量控制对患者肥胖指标的改善效果更好。
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