目的：探讨肿瘤间质比例（ SP）与结直肠癌病理特征及患者预后的关系。方法应用图像分析软件计算我院病理科2009-2012年存档的121例石蜡包埋结直肠癌手术切除标本HE染色切片中肿瘤间质面积占切片面积的比例，采用χ2检验等方法分析其与肿瘤临床病理特征的关联，结合随访资料利用生存函数分析其与患者预后的关系。结果结直肠癌组织平均SP为（45.8±17.3）％，符合正态分布。将SP≥50％定为间质高比例，＜50％定为间质低比例，间质高比例肿瘤占所有肿瘤的32.2％（39/121）；间质高比例与低比例肿瘤在浸润深度、肿瘤复发/转移上差异有统计学意义（ P＜0.05），而在患者年龄、性别、部位、组织学分级、淋巴结转移及TNM分期上差异无统计学意义（ P＞0.05）。间质高比例患者无进展生存时间比低比例患者短（中位生存时间29.2个月比34.3个月），差异有统计学意义（ P＝0.045）；总生存时间亦短（中位生存时间33.5个月比36.8个月），但差异无统计学意义（ P＝0.078）。结论结直肠癌组织中SP呈正态分布，间质高比例与肿瘤浸润范围广及患者无进展生存时间短密切相关，可能是结直肠癌独立的预后因子。%Objective To investigate the relationship between stroma portion and the clinicopathologic features of colo -rectal cancer and patients′prognosis.Methods The image analysis software was used to measure the proportion of the stroma per-centage ( SP) in colorectal cancer routine HE stained histological sections of 121 samples archived in the department of pathology between 2009 and 2012.The association between SP and clinicopathologic variables was accessed by χ2 test.Survival function com-bined with follow-up data was used to analyze the relationship between SP and patients′prognosis.Results Of 121 analyzed samples, the mean of SP in the colorectal cancer tissues , which followed normal distribution , was 45.8% ±17.3%.39 ( 32.2%) of them had a high SP based on the cutoff value of 50%.The difference in depth of invasion and tumor recurrence /me-tastasis between high SP and low SP had statistical significance (P<0.05) and the differences in age, gender, location, histo-logical grade , Lymph Node Metastasis and TNM stage were not significant ( P>0.05 ) .High SP was associated with poor pro-gression free survival significantly (median survival time was 29.2 months vs 34.3 months) (P=0.045) .High SP was also as-sociated with shortest overall survival but insignificantly (median survival time was 33.5 months vs 36.8 months) (P=0.078). Conclusion The SP presents normal distribution in colorectal carcinoma tissues.High SP was significantly associated with inva-sion depth and poorer prognosis of colorectal cancer patients , thus may be applied as an independent prognosis factor in colorectal carcinoma.
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