Nephroticsyndrome(NS),oneofthemostcommonrenaldiseasesinchildren,isdividedintoprimary, secondary and congenital types. Hormone is a preferred clinical therapy at present. However,part of children have frequent re-currence,steroid-dependence or resistance. With the continuous development of medicine,biological agents are used gradually in clinic as a kind of novel immunosuppressive agents. This paper reviews the domestic and overseas literatures on biological treat-ment for child NS having released in recent 20 years and analyzes the effects of biological agents on primary,secondary NS in children.%肾病综合征在临床上分为原发性、继发性及先天性3种类型，是儿科最常见的肾脏疾病之一。目前临床上首选糖皮质激素治疗，但部分患儿表现为频繁复发、激素依赖或激素耐药。随着医疗水平的不断发展，生物制剂作为一类新型免疫抑制剂逐步应用于临床。本文采用医学文献检索系统查阅国内外近二十年来临床生物制剂治疗儿童肾病综合征的文献，对生物制剂对儿童原发性和继发性肾病综合征的疗效进行总结和分析。
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