Objective To analyze the effect of lemon peel extract mouth rinses on children's dental plaques. Methods A total of 120 children with dental caries aged 5-8 years who visited Tianjin Children's Hospital from March 2011 to March 2013 were divided randomly into groups A,B,C,40 in each. Group A were given lemon peel extract mouth rinse,group B given compound chlorhexidine acetate mouthwash,group C given pure water. Dental plaque index( PI)and adverse reactions re-lated to the treatments were recorded before treatment and in weeks 1,2,3 after treatment. Results There was significant difference in PI among 3 groups before treatment and in weeks 1,2,3 after treatment(Ftime =21. 670,Fgroup =3. 430,Ftotal =7. 329;Ptime =0. 001,Pgroup =0. 036,Ptotal =0. 001),there was significant difference in groups A,B and group C,but no difference between group A and B. PI decreased in groups A,B after treatment,reduced at first and then increased gradually in group C in week 1 after treatment. There was no difference in incidence of adverse reaction among 3 groups(2/40 in group A, 3/40 in group B,0/40 in group C;χ2 =2. 922,P=0. 232). Conclusion Lemon peel extract mouth rinse and compound chlorhexidine acetate mouthwash effect well on child dental plaques with good safety.%目的：探讨柠檬提取物漱口液在儿童牙菌斑中的应用效果。方法选取2011年3月-2013年3月在天津市儿童医院口腔科门诊和病房就诊的龋齿病患儿120例，按照随机数字表法分为A、B、C 3组，每组40例。A组给予柠檬提取物漱口液漱口，B组给予复方醋酸氯己定漱口水漱口，C组给予康师傅纯净水漱口。记录3组患儿治疗前及治疗后1、2、3周时牙菌斑指数（ PI）及治疗相关不良反应。结果3组患儿治疗前及治疗后1、2、3周时PI比较，差异有统计学意义（F时间=21.670，F组间=3.430，F交互=7.329；P时间=0.001，P组间=0.036，P交互=0.001），其中治疗后1、2、3周时A、B组PI均低于C组，差异有统计学意义（ P<0.05），A、B两组间差异无统计学意义（ P>0.05）。A组和B组患儿治疗后PI呈下降趋势，C组治疗后1周时降低后逐渐升高。3组患儿不良反应发生率（ A组2/40，B组3/40，C组0/40）比较，差异无统计学意义（χ2=2.922，P=0.232）。结论柠檬提取物漱口液与复方醋酸氯己定漱口液效果相当，对儿童牙菌斑有抑制和治疗作用，安全性较好。
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