首页> 中文期刊> 《中国全科医学》 >全血细胞参数对40岁以下ST段抬高心肌梗死的预测价值研究

全血细胞参数对40岁以下ST段抬高心肌梗死的预测价值研究

摘要

Objective To explore the prognostic value of hematologic parameters on young STEMI patients under 40 years old. Methods From September 2012 to September 2013,a total of 61 consecutive STEMI patients less than 40 year old who were admitted in Beijing Anzhen Hospital within 6 hours after symptom onset and received emergency percutaneous coronary intervention( PCI)were retrospectively analyzed. A total 61 patients between 45 to 70 year old with STEMI receiving the treatment of PCI at the same time and 61 healthy young patients under 40 year old matched with gender were separated into young group,ol-der group and placebo group. Hematologic parameters were measured at admission and 3 months after PCI in young and older pa-tients with STEMI. Results The differences of age,hypertension rate,diabetic mellitus rate and LDL-C between the young group and older group were significant(P<0. 05);hypertension rate,smoking rate,family history of coronary heart disease rate,TG,HDL-C、,FBS and HbA1c between the young group and placebo group were significantly different(P<0. 05). On admission,WBC and neutrophil count of young STEMI patients were higher than those of older ones( P <0. 05 );after three months' treatment,hematological parameters compare between the two groups showed no significant difference( P >0. 05 ). WBC,neutrophil count,lymphocyte count and NLR of young STEMI patients after 3 months' treatment were higher than those of placebo group( P <0. 05 ) . The multivariable logistic regression analysis showed that smoking〔OR =4. 014,95% CI =(1. 405,11. 466),P=0. 01〕and rise of WBC〔OR=1. 531,95%CI =(1. 112,2. 108),P=0. 01〕remained the inde-pendent risk factors for young STEMI,and rise of HDL-C〔OR=0. 002,95%CI =(0. 000,0. 027),P<0. 001〕was a protective factor. The optimal cut-off value of WBC was 7. 33 × 109/L,sensitivity was 53% and specificity was 87%. Conclu-sion The increasing of WBC is an independent risk factor and has predictive value for STEMI of young people under 40. The finding provides references for clinical prediction.%目的:探讨全血细胞参数对40岁以下ST段抬高心肌梗死( STEMI)的预测作用。方法回顾性分析2012年9月—2013年9月,因STEMI发作<6 h在北京安贞医院住院接受急诊经皮冠状动脉介入治疗( PCI)、年龄<40岁的患者61例;入选同期因STEMI在北京安贞医院住院接受急诊PCI、年龄在45~70岁的患者以及门诊体检年龄<40岁的健康年轻人各61例,并对性别进行匹配,分别定义为年轻组、中老年组和对照组。记录年轻组和中老年组入院时和治疗3个月后的血常规及对照组血常规。结果年轻组与中老年组STEMI患者年龄、高血压患病率、糖尿病患病率、LDL-C比较,差异有统计学意义( P<0.05);对照组与年轻组的高血压患病率、吸烟率、冠心病家族史发生率、TG、HDL-C、空腹血糖(FBS)、糖化血红蛋白(HbA1c)比较,差异有统计学意义(P<0.05)。入院时年轻组STEMI患者白细胞计数( WBC)和中性粒细胞计数高于中老年组( P<0.05);治疗3个月后两组血液学指标比较,差异均无统计学意义(P>0.05)。年轻组STEMI患者治疗3个月后WBC、中性粒细胞计数、淋巴细胞计数、中性粒细胞-淋巴细胞比(NLR)均高于对照组(P<0.05)。多因素Logistic逐步回归分析显示,吸烟〔OR=4.014,95%CI =(1.405,11.466),P =0.01〕和 WBC 升高〔OR =1.531,95%CI =(1.112,2.108),P =0.01〕是年轻人发生STEMI的独立危险因素,而HDL-C升高则是保护因素〔OR=0.002,95%CI =(0.000,0.027),P<0.001〕。WBC预测STEMI的受试者工作特征曲线( ROC曲线)下面积为0.732〔95%CI=(0.636,0.829),P<0.001〕,最佳分界点为7.33×109/L,灵敏度为53%,特异度为87%。结论 WBC升高是年轻人发生STEMI的独立危险因素,对40岁以下年轻人发生STEMI有预测价值,为临床预测提供了参考价值。

著录项

  • 来源
    《中国全科医学》 |2014年第34期|4070-4074|共5页
  • 作者单位

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

    100029 北京市;

    首都医科大学附属北京安贞医院12病区;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 R542.22;
  • 关键词

    心肌梗死; 全血细胞参数; 预测价值; 年轻人;

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