Objective To assess the effects of seasonal factors on serum 25 -hydroxyvitamin D〔25(OH)VitD〕levels in people living in Guangzhou. Methods Between January 2013 and December 2013,the 25(OH)VitD serum level was assessed in 2 205 people living in Guangzhou. The subjects according to examination month,calculated 25(OH)VitD lev-el every month,adjusted with gender,age,BMI,and analyzed combined with solar radiation,sunshine hours,rainfall amount in January to December 2013. Additionally,the proportion of VitD sufficiency(75 nmol/L or higher),insufficiency(50- <75 nmol/L)and deficiency( <50 nmol/L)monthly were estunated. Results Taking serum 25(OH)VitD as dependent variable and gender,age,BMI as independent variables,multiple linear regression analysis showed that age,gender and BMI did not effect serum 25(OH)VitD(P>0. 05). There was no significant difference in gender,age,BMI,SBP,DBP in va-rying months(P>0. 05). The average level of 25(OH)VitD was(53. 7 ±19. 0)nmol/L. The minimum value of 25(OH) VitD was(47.5 ±17.4)nmol/L,appearing in April;the maximum value was(59.8 ±20.2)nmol/L,appearing in Octo-ber. The minimum value of solar radiation was(202. 0 ± 105. 0)Wh/m2,appearing in April;the maximum was(507. 0 ±108. 1)Wh/m2,appearing in September. The minimum value was(41. 0 ± 31. 4)h,appearing in April,the maximum was(203. 7 ± 58. 9) h,appearing in September. The constituent ratio of yearly VitD deficiency was 49. 16%(1 084/2 205), there was difference in months(χ2 =65. 342,P<0. 010),higher in April than in the other months,lower in October than in the other months(P<0. 05). The constituent ratio of yearly VitD sufficiency was 16. 92%(373/2 205),there was difference in each month(χ2 =7. 491,P=0. 021). Thereinto higher in October than in the other months(P<0. 05). Conclusion VitD defficiency is very common in people living in Guangzhou and seasonal changes influence 25(OH)VitD level.%目的：探讨季节因素对广州地区人群血清25-羟维生素D〔25（OH）VitD〕水平的影响。方法选取2013年1—12月在中山大学孙逸仙纪念医院进行健康体检的广州地区居住人群2205例，均空腹采集静脉血5 ml，应用酶联免疫吸附法（ELISA）检测血清25（OH）VitD水平。将体检者按照体检月份进行分析，统计每个月体检者血清25（OH）VitD水平，用性别、年龄和BMI进行校正，结合广州地区2013年1—12月太阳辐射、日照时数和降雨量进行分析。并计算每个月体检者 VitD 充足〔25（OH）VitD≥75 nmol/L〕、VitD 不足〔50≤25（OH）VitD <75 nmol/L〕、VitD缺乏〔25（OH）VitD <50 nmol/L〕所占的比例。结果以血清25（OH）VitD为因变量，以性别、年龄、BMI为自变量，行多重线性回归分析，结果显示，年龄、性别和 BMI 对血清25（ OH ） VitD 没有影响（ P >0.05）。各月份体检者的性别、年龄、BMI、收缩压、舒张压比较，差异均无统计学意义（ P>0.05）。体检者血清25（OH）VitD平均水平为（53.7±19.0）nmol/L。血清25（OH）VitD最小值为（47.5±17.4）nmol/L，出现在4月份；最大值为（59.8±20.2） nmol/L，出现在10月份。太阳辐射最小值为（202.0±105.0） Wh/m2，出现在4月份；最大值为（507.0±108.1）Wh/m2，出现在9月份。日照时数最小值为（41.0± 31.4）h，出现在4月份；最大值为（203.7±58.9）h，出现在9月份。所有体检者VitD缺乏检出率为49.16%（1084/2205）。各月份体检者VitD缺乏检出率比较，差异有统计学意义（χ2=65.342，P<0.010），其中4月份VitD缺乏检出率均高于其他月份，10月份VitD缺乏检出率均低于其他月份（ P<0.05）。所有体检者VitD充足检出率为16.92%（373/2205），各月份VitD充足检出率比较，差异有统计学意义（χ2=7.491，P =0.021），其中10月份 VitD 充足检出率均高于其他月份（P <0.05）。结论广州地区体检者VitD缺乏情况普遍存在，季节性变化对血清25（OH）VitD的水平有影响，在制定补充方案时应按照季节调整补充剂量。
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