Objective To observe the therapeutic effect of Buyuanyixin Formula in treatment of elder patients with unstable angina with hyperlipemia. Methods Eighty - six elder patients with unstable angina and hyperlipemia from January 2009 to December 2011 were randomly divided into two groups. Patients in control group ( n =43 ) were treated by routine therapy, while patients in trial group ( n = 43 ) were treated additionally by Buyuanyixin Formula. The results of the two group in efficiency, blood lipid and blood rheology were evaluated. Results In efficiency there were 22 patients who got remarkable effect, 16 who got effect and 5 who did respond in the trial group, the difference was statistically significant as compared with 14, 17 and 12 respectively in the control group ( u = 2. 09, P < 0. 05 ). No statistical significant difference in blood lipid between the two groups was found before the treatment ( P >0. 05 ). However after the treatment, the differences in triglyceride ( TG ) [ ( 2. 12 ±0. 78 ) mmol/L vs. ( 2. 57 ±0. 82 ) mmol/L ], total cholesterol ( TC ) [ ( 5. 34 ±0. 82 ) mmol/L vs. ( 7. 12 ±0. 97 ) mmol/L ], low dense lipoprotein cholesterol ( LDL - C ) [ ( 2. 56 ±0. 53 ) mmol/L vs. ( 3. 61 ±0. 62 ) mmol/L ], and high dense lipoprotein cholesterol ( HDL - C ) [ ( 1. 62 ±0. 37 ) mmol/L vs. (1. 33 ±0. 32 ) mmol/L ] between the two groups were significant ( P < 0. 05 ). No statistical significant difference in blood rheology between the two groups was found before the treatment ( P >0. 05 ). But after the treatment, the differences in whole blood viscosity [ high shear rate: ( 4. 12 ±0. 96 ) mPa · s vs. ( 5. 34 ± 1. 05 ) mPa · s; low shear rate: ( 10. 83 ± 1. 97 ) mPa · s vs. ( 12. 93 ± 2. 14 ) mPa · s ], and plasma relative viscosity [ ( 1. 87 ±0. 64 ) mPa · s vs. ( 2. 21 ±0. 75 ) mPa · s ] between the two groups were significant ( P <0. 05 ). Conclusion The Buyuanyixin Formula is remarkably effective for elder patients with unstable angina with hyperlipemia, being able to improve the indexes of blood lipid and blood rheology.%目的 观察补元益心汤治疗老年不稳定型心绞痛伴高脂血症患者的临床疗效.方法 选择我院2009年1月-2011年12月收治的不稳定型心绞痛伴高脂血症患者86例,按患者入院号顺序随机分为观察组及对照组,每组各43例,对照组给予常规治疗,观察组在常规治疗的基础上加用补元益心汤.对比两组患者治疗效果、血脂及血液流变学情况.结果 观察组显效22例,有效16例,无效5例;对照组显效14例,有效17例,无效12例,两组治疗效果比较,差异有统计学意义(u＝2.09,P＜0.05).两组患者治疗前血脂指标差异无统计学意义(P＞0.05),治疗后观察组与对照组患者的三酰甘油(TG)[(2.12±0.78)mmol/L vs.(2.57±0.82)mmol/L ]、总胆固醇(TC)[(5.34±0.82)mmol/L vs.(7.12±0.97)mmol/L ]、低密度脂蛋白胆固醇(LDL-C)[(2.56±0.53)mmol/L vs.(3.61±0.62)mmol/L ]、高密度脂蛋白胆固醇(HDL-C)[(1.62±0.37)mmol/L vs.(1.33±0.32)mmol/L ]比较,差异均有统计学意义(P＜0.05).两组与对照组患者治疗前血液流变学指标差异无统计学意义(P＞0.05),治疗后观察组患者的全血黏度[高切:(4.12±0.96)mPa·s vs.(5.34±1.05)mPa·s;低切:(10.83±1.97)mPa·s vs.(12.93±2.14)mPa·s]、血浆黏度[(1.87±0.64)mPa·s vs.(2.21±0.75)mPa·s]比较,差异均有统计学意义(P＜0.05).结论 补元益心汤治疗老年不稳定型心绞痛伴高脂血症患者疗效显著,能够显著改善血脂以及血液流变学指标.
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