头颈癌是全球范围内第五大常见肿瘤,在欧美约占全部恶性肿瘤的10%,在我国则较为多见,占19.9%～30.2%.头颈癌是一大类疾病,它们有着许多相同或相似的特征.临床上70%～80%的患者就诊时已为局部晚期,对于这部分患者,手术和放射治疗的进步并未带来长期生存率的改善.因此,头颈癌治疗的关键在于有效的早期诊断.随着蛋白质组学及其技术的发展,有希望早期发现头颈癌的标志物.本文主要对头颈癌蛋白质组学研究及肿瘤相关蛋白的表达情况作一简述.%Head and neck carcinoma is the fifth common tumor globally, accounting for less than 10% of all malignant tumors in Europe and America, while it is more common in China, accounting for 19. 9% to 30. 2%. Head and neck carcinomas , a large class of diseases, have a lot of identical or similar characteristics with each other. In clinical practice, about 70% ~ 80% of the patients are locally advanced, for whom operation and radiotherapy progress can not increase the long - term survival rate. Therefore, the key point of the treatment of head and neck carcinoma is early diagnosis. With the development of pro-teomics technology, it may be a reality for us to discover the early markers for early detection of head and neck carcinoma. This article is mainly a general literature review of head and neck carcinoma proteomics research and the expression of tumor related proteins.
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