目的 观察单纯蓝光、蓝光联合茵栀黄、蓝光联合茵栀黄及双歧杆菌三联活菌治疗新生儿黄疸的疗效,探讨茵栀黄及双歧杆菌三联活菌辅助蓝光用于新生儿黄疸治疗的必要性.方法 黄疸新生儿424例,随机分为蓝光(A组)、蓝光联合茵栀黄(B组)、蓝光联合茵栀黄及双歧杆菌三联活菌组(C组),观察3组患儿黄疸消退时间及经皮胆红素水平的变化情况.结果 A组、B组和C组黄疸消退时间分别为(8.8±3.1)d、(6.6±2.6)d、(4.3±2.2)d,3组比较差异有统计学意义(F=104.80,P＜0.01);其中B组和C组黄疸消退时间较A组均明显缩短,差异有统计学意义(P＜0.01);C组黄疸消退时间较B组明显缩短,差异有统计学意义(P＜0.01).3组患儿治疗前、治疗第1天、第2天、第3天经皮胆红素水平比较,差异均无统计学意义(P＞0.05);3组患儿治疗第4天、第5天、第6天、第7天经皮胆红素水平比较,差异均有统计学意义(P＜0.05);其中B组和C组经皮胆红素水平较A组均明显降低,差异有统计学意义(P＜0.01);C组经皮胆红素水平较B组均明显降低,差异有统计学意义(P＜0.01).结论 茵栀黄和双歧杆菌三联活菌可加强蓝光治疗的退黄疗效,值得临床推广.%To observe the clinical efficacy of phototherapy, phototherapy combined with Yinzhihuang, phototherapy combined with Yinzhihuang and bifidobacterium triple viable capsules in the treatment of 424 cases of neonatal jaundice and to analyze the need of using bifidobacterium triple viable capsules and Yinzhihuang combined with phototherapy in treating neonatal jaundice. Methods 424 cases of neonatal Jaundice were randomly divided into three groups; phototherapy ( group A ), phototherapy combined with Yinzhihuang ( group B ), phototherapy combined with Yinzhihuang and bifidobacterium triple viable capsules ( group C ) . The disappearing time of jaundice and the changes of transcutaneous bilirubin of the three groups were observed. Results The disappearing time of jaundice in the three groups was ( 8. 8 ±3. 1 ) d, ( 6. 6 ±2. 6 ) d and ( 4. 3 ± 2.2) d respectively, and the differences between the three groups were statistically significant ( F = 104. 80, P < 0. 01). The disappearing time in group B and group C was significantly shorter than that of the group A ( P < 0. 01 ) . The disappearing time of group C was significantly shorter than that of the group B ( P <0. 01 ) . The levels of transcutaneous bilirubin before treatment, one day after treatment, two days after treatment and three days after treatment showed no statistically significant differences a-mong the three groups ( P > 0. 05 ) . While the levels of nans cutaneous bilirubin four days after treatment, five days after treatment , six days after treatment and seven days after treatment showed statistically significant differences among the three groups ( P < 0. 05 ), with the levels of group B and group C significantly lower than that of group A ( P < 0. 01 ) and the level of group C significantly lower than that of group B ( P < 0. 01 ) . Conclusion Phototherapy combined with bifidobacterium triple viable capsules and Yinzhihuang granules is effective in the treatment of neonatal jaundice without adverse drug reaction.
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