儿童及青少年肥胖与甲状腺功能密切相关,其关联的可能原因有:甲状腺自身免疫状态、瘦素、炎症因子、甲状腺激素抵抗、线粒体功能受损等.甲状腺激素影响肥胖,但血清促甲状腺素(TSH)轻度升高更像是肥胖的结果而不是引起肥胖的原因,因此对于这部分儿童的甲状腺激素治疗没有必要.甲状腺激素类似物GC-1是否能用于治疗儿童及青少年肥胖仍有待研究.%There is close relationship between obesity and thyroid function in children and adolescent. The causes of the relationship may include the autoimmunity of thyroid, the role of leptin, impact of inflammatory factors, thyroid hormone resistance and consequence of impaired mitochondrial function. The thyroid hormone may have effect on obesity, but the TSH increase in obese children and adolescent seems to be a consequence rather than a cause of obesity. Therefore, this kind of increase of TSH should not be treated with thyroxine in obese children. Whether the synthetic analogue of thyroxine GC - 1 can be used to treat o-besity in children and adolescent should be further researched.
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