Objective To evaluate the short - term efficacy and safety of hemoperfusion in the treatment of refractory hyperlipidemia. Methods 32 patients with refractory hyperlipidemia were enrolled and treated with hemoperfusion for 120 minutes. Total cholesterol ( TC ), triglyceride ( TG ), low - density lipoprotein ( LDL ) and high - density lipoprotein ( HDL ) were detected before and after hemoperfusion respectively. Results The levels of TC, TG and LDL were significantly decreased compared with those before the treatment ( P < 0. 05 ), but there was no statistically significant difference in HDL before and after the treatment ( P > 0. 05 ) . Side effects were found in five out of the thirty - two patients, of which three patients had lower blood pressure, one patient had palpitation, anhelation and thorax suffocation, and one had shivering. Conclusion Hemoperfusion is safe and effective in the treatment of refractory hperlipidemia by significantly improving biochemical indicators of blood lipid and reducing cardiovascular disease risk. It should be recommended in clinic by primary hospital.%目的 探讨血液灌流治疗难治性高脂血症的短期疗效和安全性.方法 选择32例难治性高脂血症患者,给予血液灌流治疗120min,测定血液灌流前后血浆总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)的水平.结果 血液灌流治疗后TC、TG、LDL水平较治疗前均降低,差异有统计学意义(P＜0.05);治疗前后HDL水平比较差异无统计学意义(P＞0.05).32例患者中有5例发生不良反应,其中血压下降3例,心悸、气促、胸闷1例,寒战1例.结论 血液灌流治疗难治性高脂血症是一种安全有效的方法,可明显改善血脂生化指标,减轻心血管危险因素,值得在基层医院临床推广应用.
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