Objective To investigate the role of Catechol - 0 - Methyl Transferase ( COMT ) in the pathogenesis of severe pre - eclampsia by detecting its expression in the placenta of severe pre - eclampsia patients. Methods Expression of COMT in the placenta of 15 pregnant patients with severe pre - eclampsia in treatment group and 15 normal pregnant women in control group was detected by western - blotting. Results The expression level of COMT in the placental tissue of the treatment group was significantly different from that of the control group ( P < 0. 05 ) . Conclusion The expression level of COMT in the placental tissue of severe pre - eclamptic patients is lower than that of the normal pregnant women, indicating that COMT may take part in the pathogenesis of severe pre - eclampsia.%目的 检测重度子痫前期孕妇胎盘组织中儿茶酚-O-甲基转移酶(COMT)的表达量,探讨其在重度子痫前期发病机制中的作用.方法 选择重度子痫前期孕妇15例(病例组),正常孕妇15例(对照组),采用蛋白印迹方法(western blotting)检测两组胎盘组织中COMT蛋白的表达量.结果 病例组和对照组胎盘组织中COMT蛋白表达量比较,差异有统计学意义(P＜0.05).结论 重度子痫前期孕妇胎盘组织中COMT蛋白的表达量低于正常孕妇,提示COMT蛋白可能参与了重度子痫前期的发病.
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