In patients with ALI/ARDS, mechanical ventilation with lung protective ventilation strategies results in decreased mortality and enhances the number of days without ventilator use. While guidelines now strongly advise using lung protective ventilation in ALI/ARDS patients, there are presently no widely agreed - upon guidelines for the use of ventilation with lung protective ventilation strategies in patients who with non - ALI/ARDS conditions. Literatures concerning animal and clinical studies on lung protective mechanical ventilation in patients with non - ALI/ARDS conditions were searched out, and aspects including post ventilation oxygenation indices, cytokine levels, and lung histology were reviewed. The inconsistent results from different trials, however, do not definitely support the use of lung protective mechanical ventilation. Nevertheless, more prospective studies are needed to establish the optimal ventilator management strategies for patients with non - ALI/ARDS conditions.%机械通气时采取肺保护性通气策略有利于急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)患者缩短机械通气时间,降低病死率,在临床中已广泛应用.但是对于非ALI/ARDS的患者是否也采取肺保护性通气策略意见并不一致.现综述近年来的研究情况,包括机械通气后氧合指标、细胞因子水平和肺组织结构等方面的变化.目前对于肺保护性通气策略是否有利于避免非ALI/ARDS患者肺损伤的发生,研究结果并不一致,尚无明确结论.
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