Objective To explore the characteristics and clinical values of cerebrospinal fluid cytology in children with viral encephalitis. Methods Eighty children with viral encephalitis were enrolled as the case group and 40 children without central infectious disease were included as the control group. Abnormality rates of cerebrospinal fluid routine examination, cerebrospinal fluid biochemistry examination and cerebrospinal fluid cytology examination were compared between the two groups. Results The frequency of transformation lymphocyte was 87. 5% and the abnormality detection rates were 41. 2% , 37. 5% , and 78. 8% for cerebrospinal fluid routine examination, cerebrospinal fluid biochemistry examination and cerebrospinal fluid cytology examination respectively in the case group ( P <0. 01 ) . Positive rates in the case group were 78. 8% before treatment and 7. 5% after treatment with significant difference ( P <0. 01 ) . Conclusion Cerebrospinal fluid cytology examination plays an important role in the diagnosis of viral encephalitis and in evaluation of treatment effects.%目的 探讨病毒性脑炎患儿急性期脑脊液细胞学变化特点及临床价值.方法 病毒性脑炎患儿80例为病例组,非中枢感染性疾病患儿40例为对照组,对比分析两组脑脊液常规、生化和细胞学检查异常检出率.结果 病例组转化型淋巴细胞出现率(87.5%)最高.病毒性脑炎患儿脑脊液常规、生化和细胞学检查异常检出率分别为41.2%、37.5%和78.8%,差异有统计学意义(P＜0.01);病例组治疗前、后脑脊液细胞学阳性检出率为78.8%和7.5%,差异有统计学意义(P＜0.01).结论 病毒性脑炎患儿脑脊液细胞学检查对该病的诊断具有重要的临床价值,且对评价治疗效果具有一定的作用,作为一种辅助检查值得在临床上推广.
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