目的 探讨颅内外动脉狭窄支架植入手术前后血清胱抑素C(Cys-C)的水平变化及其对动脉再狭窄的影响.方法 选取2008-2010年47例颅内外动脉狭窄患者进行血管内支架植入术治疗,术后6～12个月复查数字减影血管造影(DSA),分别于术前、术后3 d和复查DSA时检测患者血清Cys-C水平,并对比分析动脉再狭窄组与未狭窄组的血清Cys-C水平.结果 术后6～12个月复查DSA显示,21例(44.7%)患者出现了再狭窄,其中13例再狭窄率＜50%,8例再狭窄率≥50%,26例患者未发现血管明显再狭窄.再狭窄组术前及术后3 d的血清Cys-C水平分别与未狭窄组比较,差异均无统计学意义(P＞0.05);再狭窄组和未狭窄组术后3 d的血清Cys-C水平与术前比较,差异均有统计学意义(P＜0.05);再狭窄组术后6～12个月的血清Cys-C水平分别与术前及未狭窄组比较,差异均有统计学意义(P＜0.05).结论 支架术后血清Cys-C水平的增高可能与再狭窄有关,并可能成为评价缺血性脑血管病复发的一个指标.%Objective This paper describes the change of serum cystatin C ( Cys - C ) brought by the stent implantation for intracranial or extracranial arterial stenosis and the influence to restenosis. Methods The stent implantation ( 2008- 2010 ) for 47 patients with intracranial or extracranial arterial stenosis were chosen. We recheck the Digital Subtraction Angiogra-phy ( DSA ) 6 ~ 12 months after the stent implantation, detect the 3 d Cys - C before and after the operation and the Cys - C when the DSA was rechecked. Then we compare and analyze the Cys - C of the restenosis group and that of the normal group. Results The rechecking of the DSA 6 ~ 12 months after the operation showed that 21 patients ( 44. 7% ) had restenosis, among which in 13 cases, the rate of restenosis was less than 50% , in 8 cases the rate was no less than 50% , 26 patients had no obvious restenosis. Compared with the normal group, before and after the operation, the 3 d Cys - C of the restenosis group had no statistical significance ( P > 0. 05 ) . The 3 d Cys - C of both the restenosis group and the normal group were higher than that before the operation ( P < 0. 05 ); the Cys - C of the restenosis group was higher than that of the normal group, when the DSA was rechecked 6 ~ 12 months after the operation ( P <0. 05 ) . Conclusion The increase of Cys - C after the stent implantation may be related to restenosis, which might become an index to analyze the relapse of ischemic cerebrovascular disease.
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