Discrimination of toxic ingredient between raw and processed Pinellia ternata by UPLC/Q-TOF-MS/MS with principal component analysis and T-test

Xing-ying Zhai1; Ling Zhang1; Bing-tao Li1; Yu-lin Feng1; Guo-liang Xu1; Hui Ouyang1; Shi-lin Yang1; Chen Jin1

首页> 中文期刊> 《中草药：英文版》 >Discrimination of toxic ingredient between raw and processed Pinellia ternata by UPLC/Q-TOF-MS/MS with principal component analysis and T-test

Discrimination of toxic ingredient between raw and processed Pinellia ternata by UPLC/Q-TOF-MS/MS with principal component analysis and T-test

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Objective: To investigate the toxicity difference between raw and processed Pinelliae Rhizoma(Banxia in Chinese, BX), the rhizoma of Pinellia ternata, from the view of chemical composition.Methods: Sixteen samples of raw and processed BX were prepared and analyzed by UPLC/Q-TOF-MS/MS.The discrimination(chemical marker) between the two group was investigated by principal component analysis(PCA) and T-test analysis. According to the accurate charge-to-mass ratio, MS/MS fragments, and comparison of corresponding data with the reference or database, the chemical markers were identified preliminarily.Results: Liquiritin, liquiritigenin, and lysophosphatidylcholine(LPC) were identified as the characteristic markers. The reducing of LPC in processed BX was one of the main reasons for detoxification because LPC could induce the inflammatory response;Liquiritin and liquiritigenin showed the anti-inflammatory effect and reduced liver injury, therefore the appearance of them in processed BX was an another reason for detoxification.Conclusion: An approach to explain the mechanisms of reducing the toxicity in medicinal plants by processing was proposed. Moreover, the chemical markers of toxicity could be used to differentiate the raw material from processed herbs for the quality control and safety application in clinical practice.

著录项

来源
《中草药：英文版》 |2019年第2期|P.200-208|共9页
作者
Xing-ying Zhai1; Ling Zhang1; Bing-tao Li1; Yu-lin Feng1; Guo-liang Xu1; Hui Ouyang1; Shi-lin Yang1; Chen Jin1;
展开▼
作者单位

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

[1]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

展开▼
原文格式 PDF
正文语种 CHI
中图分类医药、卫生;
关键词
discrimination; principal component analysis; raw and processed Pinellia ternata(Thunb.); Berit.; toxic ingredient; T-test; UPLC/Q-TOF-MS/MS;

机译：鉴别;主要成分分析;半成品和半夏;甜菊;有毒成分;T检验;UPLC / Q-TOF-MS / MS;

Discrimination of toxic ingredient between raw and processed Pinellia ternata by UPLC/Q-TOF-MS/MS with principal component analysis and T-test

摘要

著录项

相关主题

期刊订阅