建立了液相色谱-串联质谱法(LC-MS/MS)同时测定食品接触材料中28种初级芳香胺(PAAs)迁移量的方法.采用C3色谱柱,以甲醇-水为流动相,梯度洗脱分离,在电喷雾正离子模式下以多反应监测(MRM)方式检测,外标法定量.28种PAAs检出限(LOD,S/N=3)和定量限(LOQ,S/N=10)分别为0.02～0.3 μg/kg和0.1～ 1.0μg/kg;在1.0 ～ 1000 μg/L浓度范围内线性良好,相关系数大于0.9915；加标浓度在1.0～100 μg/kg的回收率为77.8％ ～ 105.3％;相对标准偏差(RSD)为4.5％ ～11.8％.本方法操作简便、快速、准确、灵敏度高,能满足相关测定要求.%A method was developed for simultaneous determination of the migration of 28 kinds of primary aromatic amines(PAAs) from food contact materials by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analytes were separated on a C3 column,eluted by gradient with methanol and water, identified by electrospray ionization mass spectrometry in positive mode using multiple reaction monitoring ( MRM) , quantified by external standard method . The limits of detection (LOD, S/N=3) and quantification (LOQ, S/N-10) of 28 PAAs were 0.02-0.3 μg/kg and 0. 1-1.0 μg/kg, respectively. The correlation coefficients of linear calibration curve were over 0. 9915 in the ranges varied from 1. 0 μg/L to 1000 μg/L. The recoveries of PAAs were 77. 8% -105. 3% in the spiked range of 1.0-100 μg/kg, and the relative standard deviation (RSD) was 4.5%-11. 8% . The experiment results indicated that the method was simple, rapid, sensitive, accurate, and could meet the correlative requirements for determination.
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