Clinical efforts to repair damaged articular cartilage(AC)currently face major obstacles due to the limited intrinsic repair capacity of the cartilage tissue.Thus,it is essential to understand the molecular mechanisms involved in the chondrogenic differentiation.It is known that miRNAs play a significant role in chondrogenic differentiation.In this study,the expression of miR-222-3p and the level of autophagic activity were investigated during chondrogenic induction in ATDC5 cells.The results showed that miR-222-3p was down-regulated significantly and the level of autophagic activity was enhanced during this process,and there was a negative correlation between them.Moreover,inhibition of miR 222-3p promoted chondrogenic differentiation and inhibited hypertrophic differentiation of ATDC5 cells,as supported by enhancing the gene and protein expression of chondrocyte specific markers of SOX9,aggrecan and collagen type II(Col2a1),but reduced the expression of hypertrophic differentiation marker collagen type X(Col10a1).In contrast,inhibiting autophagic activity decreased chondrogenic differentiation and promoted hypertrophic differentiation of ATDC5 cells.
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机译：Retraction statement: ‘Formin‐like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer’ by Yuanfeng Zeng Huijun Xie Yudan Qiao Jianmei Wang Xiling Zhu Guoyang He Yuling Li Xiaoli Ren Feifei Wang Li Liang and Yanqing Ding
