Objective To investigate the relationship between clinical efficacy of the drug and its treatment time for patients with diopathic teratospermia. Methods Total of 228 patients with idiopathic teratospermia who were treated with VC+VE+ folic acid+ l-carnitine + undecanoic acid testosterone therapy in the Reproductive Center of the Second Hospital of Jilin University from Sep.2011 to Apr. 2013 were retrospectively reviewed. The percentages of normal sperm morphology before treatment and after 3 and/or 6 months treatment were statistically analzyed. Results After 3 months treatment, the effective rate was 68.32%, it was obviously improved in the percentage of normal morphology sperm compared to that of pre-treatment (P<0.05). After 6 months treatment, the effective rate was 81.99%, it was obviously improved in the percentage of normal morphology sperm compared to that of pre-treatment(P<0.05).There was significant different in the percentage of normal morphology sperm between patients treated for 6 months and patients treated for 3 months (P<0.05). Conclusion VC+VE+folicacid+l-carnitine+ undecanoic acid testosterone therapy can obviously improve the percenrage of normal morphology sperm in patients with idiopathic teratospermia. Efficacy of long term treatment (6 months) is superior to that of short term treatment (3 months).%目的：探讨特发性畸形精子症药物治疗效果及与治疗时间的关系。方法回顾性选择2011年9月至2013年4月就诊于吉林大学第二医院生殖医学中心男科门诊确诊为特发性畸形精子症、予以VC+VE+叶酸+左旋肉碱+十一酸睾酮方案治疗的患者，共228例，收集治疗前、治疗3个月后和（或）6个月后正常形态精子百分比，并予以统计学分析。结果治疗3个月后，有效率68.32%，正常形态精子百分比较治疗前明显提高（P＜0.05）；治疗6个月后，有效率81.99%，正常形态精子百分比较治疗前明显提高（P＜0.05）；连续治疗6个月比治疗3个月正常形态精子百分比提高更明显，差异有统计学意义（P＜0.05）。结论维生素C+维生素E+叶酸+左旋肉碱+十一酸睾酮方案可提高正常形态精子百分比；治疗6个月效果优于3个月。
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