目的：探讨精索静脉曲张（VC）患者血清性激素变化及对生育功能的影响。方法回顾分析2010年8月至2013年5月在我院就治的76例VC患者，根据患者是否具有生育能力，分为生育组（A组，n=41），年龄27±2.05（22~39岁），不育组（B组，n=35），年龄28±3.17（20~41）岁。有生育功能的正常志愿者为对照组（C组，n=30），年龄28±2.35（23~38）岁。采用ELISA双抗体夹心法测定各组患者血清性激素，计算机辅助精液分析（CASA）比较各组精液参数。结果精索静脉曲张不育组精子密度、精子活力、血清抑制素B（InhB）显著低于正常对照组和生育组（P ＜0.05），畸形精子、血清卵泡刺激素（FSH）显著高于正常对照组和生育组（P＜0.05），血清黄体生成素（LH）显著高于生育组，精浆量、血清睾酮（T）与生育组和正常对照组比较无统计学意义（P＞0.05）；VC生育组精子密度显著高于正常对照组（P＜0.05），其他精液参数和血清FSH、InhB、LH、T与正常对照组比较无统计学意义（P＞0.05）。结论精索静脉曲张不育患者血清性激素水平明显发生异常，对患者的生育功能产生显著影响。%Objective To investigate the changes of sexual hormones in patients with varicocele and explore its effect on fertility. Methods Clinical data of 76 patients with varicocele in our hospital from August 2010 to May 2013 were retrospectively analyzed. According to reproductive function status, they were divided into two groups such as fertility group (A, n = 41, aged 27 ± 2.05 years old), infertility group (B, n = 35, aged 28 ± 3.17 years old). The volunteers with normal reproductive function were defined as the control group (C group, n = 30), aged 28 ± 2.35 (23~38 years old). The levels of serum sex hormones were detected by ELISA, and semen parameters were determined by computer-aided sperm analysis (CASA). Results Sperm concentration, sperm motility, plasma InhB in the infertile group were significantly lower than those in the control group and the fertile group (P<0.05), whereas abnormal sperm, plasma FSH were significantly higher than those in the control group and the fertile group (P<0.05) , the level of LH was significantly higher than that in fertile group, seminal volume, plasma T compared with the fertility group and the normal control group was not statistically significant (P>0.05); Sperm density in the fertile group was significantly higher than that in the normal control group (P <0.05), other semen parameters and plasma FSH, InhB, LH, T compared with the normal control group was not statistically significant (P>0.05). Conclusion The level of serum sex hormone in infertile patients with varicocele was significantly abnormal, resulting in a significant impact onpatients’ reproductive function.
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