Objective To evaluate the relationship between age, clinical symptomatic parameters, prostate volume and the level of serum prostate specific antigen (PSA) in patients with benign prostatic hyperplasia. Methods Clinical data of 141 patients including age, clinical symptomatic parameters, prostate volume and serum PSA concentration were collected and analyzed by software SPSS 10.0. Results Total prostate volume, transition zone volume and level of serum PSA were all increased with age(P＜0.05); The level of serum PSA were increased with the total volume and transition zone volume of the prostate (P＜ 0.01). Multiple linear regression analyses showed that only the prostate transition zone volume was correlated with the level of serum PSA(P＜0.01), whereas other factors werenot correlated with the level of serum PSA (P＞ 0.05). Conclusion The total prostate volume, transition zone volume and serum PSA levels all increased with age for patients with benign prostatic hyperplasia. Prostate transition zone volume might be the principal reason for serum PSA changes.%目的 探讨前列腺增生(BPH)患者的年龄、临床症状参数、前列腺体积与血清前列腺特异性抗原(PSA)之间的关系.方法 采用SPSS 10.0软件总结并分析141例BPH患者年龄、临床症状参数、前列腺体积与血清PSA之间关系.结果 对患者年龄分组后显示前列腺总体积、移行区体积、血清PSA值随患者年龄增长而增加(P＜0.05);对患者血清PSA值分组后显示血清PSA值随前列腺总体积增加而升高(P＜0.01),血清PSA值随前列腺移行区体积增加而升高(P＜0.01).多元线性回归分析得出只有前列腺移行区体积与血清PSA值有相关性(P＜0.01),其他因素与血清PSA值之间均没有相关性(P＞0.05).结论 BPH患者前列腺总体积、移行区体积和血清PSA水平随患者年龄增长而增加.前列腺移行区体积是导致血清PSA值变化的最主要因素.
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