Objective:To explore the effects of Dabuyin pills and its modification on FSH, LH, body weight and adrenal index adopting ovariectomized rats model,and investigate its mechanism in the treatment of climacteric syndrome. Methods; Rats model of climacteric syndrome was built by surgical transplant, and were randomLy divided into the control group, model group,Dabuyin pills group and a medicamentum diversified from Dabuyin pills group. The content of serum FSH,LH were determined with radioimmunoassay,and the weight of rats, adrenal index were detected. Results; Compared with the model group, the content of serum FSH, LH and the body weight of Dabuyin pills group and its medicamentum diversified lowered significantly, and the adrenal index increased. Conclusion: Dabuyin pills and its medicamentum diversified can correct the model rats FSH, LH hormone levels, can alleviate the situation of adrenal atrophy in ovariectomized female rats to a certain extent, consequently restore the endocrine function and relieve the clinical symptoms.%目的:观察大补阴丸及加减方对去卵巢大鼠(OVX)血清性激素FSH、LH及体质量、肾上腺指数影响.方法:以OVX大鼠为动物模型,分为空白对照组、模型组、大补阴丸组、大补阴丸加减组和阳性对照组,采用ELISA方法,观察各组大鼠血清中FSH、LH变化,并对大鼠体质量、肾上腺指教进行检测.结果:大补阴丸及加减方能显著降低OVX大鼠LH、FSH及体质量水平,明显升高肾上腺指数.结论:大补阴丸及加减方可纠正OVX大鼠FSH、LH激素水平,缓解肾上腺萎缩状况.
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