Hyperlipidemia syndrome (Phlegm accumulates with stagnant blood syndrome) is easily to cause disorder or damage of vascular endotheliocyte,which in turn induce angina pectoris of coronary heart disease under stimulation of many kinds of pathogenic factors. According to the theory of Traditional Chinese Medicine,the occurrence of “Xiong Bi” is due to the phlegm and blood stasis which blocks heart meridian. One hypothesis of the mechanisms of phlegm accumulates with stagnant blood are increase of lipoid peroxide,oxygen free radical,attachment of lipoid to vascular endothelia cell,and injury of vascular system. which provides theory basis for study the pathogenesis of angina pectoris of coronary heart disease.%高脂血症(痰瘀互结证)易致血管内皮功能紊乱或损伤，在各种致病因素的刺激下诱发冠心病心绞痛的发作。中医认为“胸痹”的发生是由于“痰瘀互结，阻塞心脉”。痰瘀互结证的物质基础可能是脂质过氧化、氧自由基增多，脂性物质附着在血管内皮上，逐渐损伤血管内皮的病理过程。此假设为研究冠心病心绞痛的发病机制提供理论基础。
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