Objective To study repairing effect of Lugua polypeptide on patients with spinal cord injury and the related mechanism. Methods From August 2012 to August 2013,79 cases patients with thoracolumbar spinal cord injury as the research objects,and they were divided into two groups randomly.The control group (n=38)received conventional treatment,and the observation group (n=41)received intravenous drip of Lugua polypeptide on the basis of conventional treatment.The course is three months.The American spinal injury association(ASIA)sensory score,ASIA motor score and Bathel index (BI )were recorded in two groups before and after treatment.Analyse the repairing effect on patients with spinal cord injury. Results ASIA sensory score,ASIA motor score and Bathel index in two groups after treatment improved ,and the observation group improved significantly compared with control group(P<0.05).Conclusion Lugua polypeptide can improve sensory and motor function with spinal cord injury ,it has clinical value.%目的：研究鹿瓜多肽对患者脊髓损伤的修复作用及相关机制。方法以2012年8月～2013年8月间收治的79例胸腰段脊髓损伤患者为研究对象，按照随机数字表，随机分为2组。对照组（n＝38），行常规治疗；观察组（n＝41），在常规治疗的基础上配合静脉滴注鹿瓜多肽，疗程3个月。记录患者治疗前后的美国脊髓损伤协会（the American spinal injury association，ASIA）感觉评分、ASIA运动评分、巴氏指数（Bathel index，BI），分析患者脊髓损伤修复情况。结果2组患者在治疗后，ASIA感觉评分、ASIA运动评分、BI评分均较治疗前增加，但观察组提升幅度更显著，3项评分相较于对照组，差异均有统计学意义（P＜0.05）。结论鹿瓜多肽能够改善脊髓损伤患者感觉及运动功能，有临床推广价值。
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