Pharmacokinetics, Biodistribution and Elimination of Recombinant Human Homoserine Thymosin in Rats and Mice

MA Jian-xiu; LEI Ze-lin; ZHONG Jian-bing; MA Yan-qing; JIN Long

首页> 中文期刊> 《中国生物医学工程学报（英文版）》 >Pharmacokinetics, Biodistribution and Elimination of Recombinant Human Homoserine Thymosin in Rats and Mice

Pharmacokinetics, Biodistribution and Elimination of Recombinant Human Homoserine Thymosin in Rats and Mice

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Objective:To study the pharmacokinetic,distribution and elimination properties of rhT α 1 after intravenous (i.v.) and subcutaneous (s.c.) injection in mice and rats.Methods:Competition ELISA was used for testing drug concentration in serum,urine,bile and tissue after administration of rhT α 1 in mice (0.16,0.5,2.5 mg/kg) and rats (0.32,1,5 mg/kg).Pharmacokinetic parameters were calculated by WinNolin software.Results:Absorption of rhTα 1 is rapid in both mice and rats after s.c.administration.The pharmacokinetics in mice are characterized by linear,T1/2 showed a prolongation with increasing dose,1.10,1.35,and 1.50 h corresponding to 0.32,1 and 5 mg/kg respectively,but in rats Ti/2 showed no difference among doses.AUC0-∞ showed a clear increase with increasing doses in mice (904.18,2998.83,and 19001.82 h*ng/rnL) and in rats (1327.56 ± 237.00,2924.53 ± 685.14,and 35286.26 ± 5999.58 h*ng/mL) After i.v.administration of 1 mg/kg rhTα1 in mice,the drug is seen distributed in most organs,the thymus/serum exposure ratio was higher than others at the 1 and 2 h,the accumulative urinary excretion of primary drug was 3297％ ± 15.85％ within 6 h.Conclusion:The results indicate that rapid absorption,extensive distribution and quick renal excretion were the basic kinetic characteristics of rhTαl after s.c.and i.v.administration.

著录项

来源
《中国生物医学工程学报（英文版）》 |2017年第3期|114-128|共15页
作者
MA Jian-xiu; LEI Ze-lin; ZHONG Jian-bing; MA Yan-qing; JIN Long;
展开▼
作者单位

School of Medicine, Northwest University for Nationalities, Gansu Province Lanzhou 730030, China;

Donggang Branch of First Hospital of Lanzhou University, Gansu Province Lanzhou 730020, China;

School of Medicine, Northwest University for Nationalities, Gansu Province Lanzhou 730030, China;

School of Medicine, Northwest University for Nationalities, Gansu Province Lanzhou 730030, China;

School of Medicine, Northwest University for Nationalities, Gansu Province Lanzhou 730030, China;

展开▼
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词

Pharmacokinetics, Biodistribution and Elimination of Recombinant Human Homoserine Thymosin in Rats and Mice

摘要

著录项

相关主题

期刊订阅