Silicon Nanowire-Based Methodology for Quantifying Single Cell Traction Force

NIU Yong-shan; YAN Ling; DAI Ming; FAN Yu-bo; LI Zhou

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Silicon Nanowire-Based Methodology for Quantifying Single Cell Traction Force

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In this paper, we present a new method, a silicon-nanowire-array based technique for quantifying the mechanical behavior of single cells, representing three distinct groups: normal mammalian cells, benign cells (L929) and malignant cells (HeLa). By culturing the cells on top of NW arrays, the maximum traction forces of different cells have been measured by quantitatively analyzing the bending of the nanowires. The elastic modulus of the as-fabricated Si-NW arrays was first measured before cell culturing. Finite element (FEM) simulations were carried out in order to derive the relationship between the applied transverse force and the corresponding tip displacement for a Si-NW. Our study is likely important for studying the mechanical properties of single cells and their migration characteristics, possibly providing a new cellular level diagnostic technique.

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《中国生物医学工程学报（英文版）》 |2018年第4期|158-164|共7页
作者
NIU Yong-shan; YAN Ling; DAI Ming; FAN Yu-bo; LI Zhou;
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作者单位

School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;

Key Lab for Biomechanics and Mechanobiology of Ministry of Education, Beihang University, Beijing 100191, China;

School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;

School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;

School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;

Key Lab for Biomechanics and Mechanobiology of Ministry of Education, Beihang University, Beijing 100191, China;

School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;

Key Lab for Biomechanics and Mechanobiology of Ministry of Education, Beihang University, Beijing 100191, China;

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正文语种 eng
中图分类生物信息、生物控制;
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Silicon Nanowire-Based Methodology for Quantifying Single Cell Traction Force

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