Objective:Evaluate the application values of 99mTc-2 β[N, N′-bis(2-mercaptoethy1)ethylenediamino]methyl, 3β-(4-chlorophenyl)tropane(TRODAT-1) dopamine transporter (DAT) SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Methods:Ten autistic children and ten healthy controls were examined with 99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of 99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striatum and cerebellum[(STR-BKG)/BKG]. Results:There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children (P=0.562) and in normal controls (P=0.573); dopamine transporter in brain of patients with autism increased more significantly than that in normal controls (P=0.017).Conclusion:Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT 99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.
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