Currently the voxel based registration methods have been used widely such as the well known mutual information (MI). Although the accuracy of their results is plausible, the registration procedure is slow. This paper proposed some methods to rigid registration based on mutual information, aiming for an acceleration of the registration process without significantly loss of precision in the final results. The efficiency of these methods is examined by registration of CT MR and PET MR. Experimental results show that the speedup is effective and efficient. By using the fast methods, the registration of 3 D medical image could also be implemented on PC rapidly.
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