Dysregulated pseudo-hypoxia(through its effects on cell survival,angiogenesis,metabolism,invasion)and epigenetic dysregulation[through widespread suppression of tumor suppressor genes involved in cell cycle,apoptosis,adhesion immune evasion,etc.(1)]are considered to be the two central driving pathogenic features in the progression of clear cell Renal Cell Carcinoma(cc RCC)(2,3).These
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