目的:探讨动态脉压及其指数与高血压患者颈动脉内膜-中层厚度(IMT)的关系.方法:测量159例研究对象的24 h动态血压,并计算动态脉压(平均收缩压-平均舒张压)及动态脉压指数(动态脉压/平均收缩压).使用彩色多普勒超声检测颈动脉IMT.分析动态脉压指数与颈动脉IMT的相关性.结果:Pearson相关分析发现,颈动脉IMT与年龄(r=0.353)、平均收缩压(r=0.594)、平均舒张压(r=-0.355)、动态脉压(r=0.855)、动态脉压指数(r=0.883)有良好的相关性(P均＜0.001).进一步行多元逐步回归分析显示,颈动脉IMT与动态脉压及动态脉压指数具有显著线性关系(R2=0.789),动态脉压指数的标准回归系数(β=0.621)大于动态脉压的(β=0.284).结论:动态脉压指数和动态脉压是评价颈动脉血管硬化的良好指标,动态脉压指数的价值更大.%Objective:To study relationship among ambulatory pulse pressure(PP),pulse pressure index (PPI) and carotid intima-media thickness (IMT) in aged patients with hypertension.Methods:The 24h ambulatory blood pressures of 159 subjects were measured,and their ambulatory PP [(mean systolic blood pressure (SBP) - mean diastolic blood pressure (DBP)] and ambulatory PPI (ambulatory PP/mean SBP) were calculated.Color Doppler ultrasonography was used to measure carotid IMT.Relationship between ambulatory PPI and carotid IMT was analyzed.Results:Pearson correlation analysis indicated that carotid IMT was correlated with age (r =0.353),mean SBP (r=0.594),mean DBP ( r =- 0.355),ambulatory PP ( r =0.855) and ambulatory PPI ( r =0.883),P ＜ 0.001 all.Multivariant gradual regressive analysis indicated that carotid IMT possessed significant linear correlation with ambulatory PP and ambulatory PPI (R2 =0.789),and standardized regression coefficient β of ambulatory PPI (β=0.621)was higher than that of ambulatory PP (β=0.284).Conclusion:Ambulatory pulse pressure index and ambulatory pulse pressure are good indicators for evaluation of carotid arteriosclerosis,and value of ambulatory pulse pressure index is more than.
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