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首页> 中文期刊> 《临床与实验病理学杂志》 >胃癌中肿瘤微环境转移的价值

胃癌中肿瘤微环境转移的价值

         
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Purpose To investigate whether or not present tumor microenvironment of metastasis ( TMEM ) in gastric cancer and its relationship with hematogenous metastases. Methods A case-control study of 26 patients who developed metastatic gastric cancer and 26 patients without metastatic disease was done. Paraffin-embedded gastric cancer samples were stained using double-immunostaining method allowing simultaneous identification of macrophages and endothelial cells. Then TMEM density was evaluated. Results ( 1 ) TMEM was present in gastric cancer. ( 2 )TMEM density was related to cancer differentiation and clinical stages ( P 0. 05 ). (3 )TMEM density had a positive correlation with distant metastasis( P <0. 001 ). Conclusions They demonstrate that TMEM is present in gastric cancer. TMEM density can predict the development of hematogenous metastases and may be a useful new prognostic marker for gastric cancer patients.%目的 研究胃癌中是否存在肿瘤微环境转移(tumor microenvironment of metastasis,TMEM)及其与胃癌血道转移的相关性.方法 采用免疫组化双染法同时标记巨噬细胞和内皮细胞,计数26例远处转移及其配对26例无远处转移胃癌组织中TMEM密度.结果 (1)TMEM存在于胃癌组织中;(2)TMEM与分化程度、临床分期明显相关(P<0.001,P=0.006),与肿瘤大小、Lauren分型、淋巴结转移等其他临床病理特点无关(P均＞0.05);(3)TMEM与有无远处转移呈正相关(P<0.001).结论 证实胃癌中存在TMEM,TMEM密度可以预测胃癌血道转移,有望成为评估胃癌血道转移危险性的新预测指标.

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