Purpose To study the clinical, histopathological and prognostic characteristics of pituitary adenoma. Methods A retrospective analysis were performed by review of clinical, radiological and prognostic data and hematoxylin-eosin and immunohistochemical stains in 108 cases of pituitary adenoma from May 2005 through December 2007. Results Of the 108 cases in our series, 45 were males and 63 females. The mean age at presentation was 48. 0 years ( range 17 ~ 89 years ). By magnetic resonance, 18 cases were mi-croadenomas, 87 were macroadenomas and the remained 3 were giant adenomas. Immunohistochemically, 50 cases were growth hormone producing adenoma, 28 prolactin producing adenoma, 11 adenocorticotropic hormone producing adenoma, 10 gonadotropin producing adenoma, 4 null cell adenomas and 5 other mixed hormones-secreting adenoma. The follow-up duration ranged from 30 months to 60 months ( median of 43. 9 months ), and 36 cases of them recurred. Conclusions The recurrence of pituitary adenoma is significantly related to the size of the tumor and whether it is completely resected ( P 0. 05 ). The close correlation of immunohistochemical results with clinical manifestations suggests that immunophenotyping might be useful in the classification, further studies and treatment of pituitary adenoma.%目的 研究垂体腺瘤的临床、病理学及预后特点.方法 收集2005年5月～2007年12月复旦大学附属上海第五人民医院神经外科病理确诊的垂体腺瘤患者108例,回顾性分析其临床、放射学、随访资料及HE染色、免疫组化染色等临床病理特点.结果 108例患者中,男性45例,女性63例,发病年龄17～89岁,平均48.0岁.根据影像学显示大小,分为微腺瘤18例,大腺瘤87例,巨大腺瘤3例.依据免疫组化结果显示生长激素(growth hormone,GH)型腺瘤50例,泌乳激素(prolactin,PRL)型腺瘤28例,促肾上腺皮质激素(adenocorticotropic hormone producing adenoma,ACTH)型腺瘤11例,促性腺激素(gonadotropin producing adenoma,FSH/LH)型腺瘤10例,裸细胞腺瘤(null cell adenoma)4例,其它混合型腺瘤5例.患者术后随访时间30～60个月,平均43.9个月,其中36例(33.3%)复发.结论 肿瘤复发与肿瘤大小及切除完整与否有关(P＜0.05),与患者年龄、性别及肿瘤免疫表型、是否侵袭无关(P＞0.05).免疫组化染色结果与患者的临床表现密切相关,可根据免疫组化结果对其进行功能性分类、研究,并指导临床治疗.
展开▼
