目的：探讨新诊断2型糖尿病（T2DM）伴腹型肥胖胰岛 A 和 B 细胞功能与血尿酸的相关性。方法149例新诊断 T2DM患者，分为腹型肥胖组（AO）74例和非腹型肥胖组（NAO）75例。检测两组患者血尿酸和空腹及馒头餐试验后30、60、120、180 min 各时间点 C 肽（CP）和胰高糖素水平。结果AO 组血尿酸与经对数转换后0、30、60、120、180 min 时间点 CP 及0、30 min 胰高糖素呈正相关（P ＜0．05）；NAO 组血尿酸与经对数转换后0、30、60、120、180 min 各时间点 CP 正相关（P ＜0．05），而与经对数转换后的各时间点胰高糖素均无相关性（P ＞0．05）；两组合并后，血尿酸与经对数转换后0、30、60、120、180 min 各时间点 CP 呈正相关（P ＜0．05），与经对数转换后的0、30 min 时间点胰高糖素呈正相关（P ＜0．05）。结论新诊断 T2DM伴腹型肥胖胰岛 A 和 B细胞功能与血尿酸具有相关性。%Objective To discuss the correlation between the the islet alpha and beta cells function and blood uric acid in the newly-diagnosed T2DMpatients with abdominal obesity.Method A total of 1 49 patients with newly di-agnosed T2DM were divided into abdominal obesity group (74 patients)and non-abdominal obesity group (75 pa-tients).Testing The blood uric acid,C-peptide(CP)and glucagon levels of patients were tested in the two groups in fast-ing and OGTT test after a time interval of 30 min,60 min,1 20 min,1 80 min.Results Blood uric acid in abdominal o-besity group was positively correlated with log-transformed CP atthe time interval of 0 min,30 min,60 min,1 20 min,1 80 min and log-transformed glucagon atthe time interval of 0 min,30 min(P <0.05).Blood uric acid in non-abdominal o-besity group was positively correlated with log-transformed C-P at the time interval of 0 min,30 min,60 min,1 20 min, 1 80 min (P <0.05)while it had no correlaation with log-transformed glucagon at any time (P <0.05).After the com-bination of the two groups,the blood uric acid was positively correlated with log-transformed CP at the time interval of 0 min,30 min,60 min,1 20 min,1 80 min(P <0.05)and log-transformed Glucagon at the time interval of 0 min,30 min (P <0.05).Conclusion Islet alpha and beta Cells function of newly-diagnosed T2DMpatients with abdominal obesity have correlation with blood uric acid.
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