近年来，胃癌的发病率和死亡率居高不下，早期发现、早期诊断、早期治疗是防治胃癌的关键。随着现代医学发展，肿瘤标志物已应用于临床诊断，但由于肿瘤标志物灵敏度和特异度较低，临床应用局限，难以满足＂精准医疗＂要求。研究表明，循环肿瘤 DNA（ctDNA）检测技术是一种快速、高效、相对无创性的新型＂液体活检＂技术，能够实时监测机体肿瘤状态、转移、复发及预后评估。本文阐述 ctDNA 与胃癌的关系，介绍目前常用的 ctDNA 检测技术，探讨 ctDNA 在胃癌临床诊疗中的应用价值。%With increasing morbidity and mortality of gastric cancer in recent years,the early detection,diag-nosis and treatment are critical to the prophylaxis and therapy of gastric cancer nowadays.Tumor markers have gain growing concern to its clinical applications but still confined to the sensitivity and specificity which make it hard to fit for"precision medicine".Some research have shown that circulating tumor DNA(ctDNA)detection is a kind of "liquid bi-opsy "technology which is rapid、effective and noninvasive.The state of tumor,including metastasis,recurrence and prognosis can be monitored by detecting ctDNA.This review focuses on the relationship between ctDNA and gastric cancer,as well as the detection technology commonly used to explore the application of ctDNA in clinical diagnosis and treatment of gastric cancer.
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