Micro RNA as important regulatory molecules widely exist in eukaryotes and participate in the process of atherosclerotic plaque progression and plaque rupture,mainly by regulation of the vascular endothelial cells,vascular smooth muscle cells,monocytes and macrophages.By screening of atherosclerosis related abnormal expression of microRNAthis research investigate the formation of influence factors in the process of regulation of atherosclerosis,this may facilitate discovering new targets for the prevention and treatment of atherosclerosis to further understand the molecular mechanism of the occurrence and development of atherosclerosis.%微小 RNA(简称miRNA)作为重要的调节分子广泛存在于真核生物中,主要通过对血管内皮细胞、血管平滑肌细胞以及单核巨噬细胞等进行调控而参与动脉粥样硬化斑块发生、斑块进展及斑块破裂的过程.筛选动脉粥样硬化相关的异常表达微小 RNA,研究其对动脉粥样硬化形成过程中相关影响因素的调控,有助于进一步了解动脉粥样硬化发生发展的分子机制以及发现预防与治疗动脉粥样硬化的新靶点.
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