目的 探讨帕金森病冻结步态临床特征及危险因素对其临床特征的影响.方法 根据患者的步态冻结症状和帕金森综合评分量表(UPDRS)评估情况,将83例帕金森病患者分为对照组(37例)和观察组(46例);比较两组患者的临床特征,分析其相关影响因素.结果 观察组患者帕金森综合评分量表1(UPDRS-Ⅰ)评分、帕金森综合评分量表2(UPDRS-Ⅱ)评分、帕金森综合评分量表3(UPDRS-Ⅲ)评分、服用左旋多巴日总量、汉密顿抑郁量表(HAMD)评分均大于对照组,且差异均有统计学意义(P<0.05);观察组患者简易智力状况量表(MMSE)评分小于对照组,且差异有统计学意义(P<0.05);观察组患者H-Y分期高于对照组,且差异有统计学意义(P<0.05);观察组患者尿酸水平低于对照组,观察组患者胱抑素C水平高于对照组,且差异均有统计学意义(P<0.05);而尿酸值、H-Y分期是帕金森病伴步态冻结症状的独立危险因素.结论 帕金森病的步态冻结症状与尿酸值、H-Y分期有关;且帕金森病伴步态冻结患者的运动功能障碍更加明显,非运动功能的损伤更加严重.%Objective To investigate the clinical characteristics and related factors of frozen gait in parkinson′s disease.Methods According to the gait in patients with frozen symptoms and Parkinson′s rating table (UPDRS) to assess the situation,83 cases of patients with Parkinson′s disease in our hospital were divided into control group (37 cases) and observation group (46 cases).The clinical characteristics were compared,and the related factors were analyzed in the two groups.Results Parkinson score scale 1,2 and 3 (UPDRS-I,UPDRS-II and UPDRS-III) scores,total scores of taking levodopa daily and Hamilton Depression Scale (HAMD) scores were all higher in the observation group patients than those in the control group,and the differences were statistically significant (P<0.05).Mini Mental Status Scale (MMSE) score of the patients in the observation group was less than that in the control group,and the difference was statistically significant (P<0.05).H-Y stage of the patients in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).The levels of serum uric acid and cystatin C in the observation group were lower and higher than those in the control group,respectively,and the differences were statistically significant (P<0.05).The uric acid value and H-Y stage were independent risk factors for gait frozen symptoms of Parkinson′s disease.Conclusion As a common complication of Parkinson′s disease,gait freezing is associated with uric acid value and H-Y stage.The motor dysfunction is obvious and the non-motor function is more serious in patients with Parkinson′s disease.
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