目的 评价内皮依赖血管舒张功能状态在老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的不同临床特征分组间的差别,分析该人群心脑血管事件意外发生的潜在危险因素.方法 36例确诊为OSAHS的老年患者被纳入本研究.采用高分辨率血管超声测量入组患者的反应性充血前后肱动脉内径的变化值并计算肱动脉内皮依赖性舒张功能(FMD)值,并检验血管舒张功能受损程度在不同临床特征分组间的差异.通过回顾性分析3年随访数据进一步研究不同临床特征分组间的心脑血管事件发生率的差异.结果 伴发高血压病的患者的FMD值[(7.85±0.65)％]明显低于不伴高血压病的患者[(8.40±0.80)％](P＜0.05).对3年随访数据的回顾性分析显示,伴有高血压病的患者的心脑血管事件发生率(41.2％,7/17)明显高于不伴高血压的患者(10.5％,2/19),P＜0.05.结论 伴发高血压病是OSAHS老年患者心脑血管意外发生的高危因素.%Objective To evaluate the difference of endothelium-dependent vasodilatation function status between two groups divided by clinical characteristics in the elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS),to identify the risk factors of cardiovascular events in the elderly OSAHS patients.Methods A total of 36 elderly patients with OSAHS were collected.Flow-mediated dilation (FMD) was calculated by change of the brachial artery caliber before and after the reactive hyperemia using high-resolution vascular ultrasonography,and the differences of vasodilation function injury degree between two groups divided by clinical characteristics were tested.The differences of the incidence of cardiovascular events between two groups were retrospective analysis according to 3-year follow-up data.Results The FMD value of OSAHS patients with hypertension [(7.85 ± O.65) ％] were significantly lower than that in the group of patients without hypertension [(8.40 ± 0.80) ％] (P ＜ 0.05).The incidence of cardiovascular events in the OSAHS patients with hypertension (41.2％,7/17) was significantly higher than that in the patients without hypertension (10.5 ％,2/19) (P ＜ 0.05) by retrospective analysis of 3-year follow-up data.Conclusion Hypertension is identified as a high-risk factor for cardiovascular events in the elderly patients with OSAHS.
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