目的：分析肾损伤因子1（Kim-1）对冠状动脉造影术后对比剂肾病发生的预测价值。方法依据接受冠状动脉造影检查患者冠状动脉造影术后是否发生对比剂肾病（CIN）分为两组，观察组（术后 CIN）及对照组（无 CIN）。比较两组的术后24 h 尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）及 Kim-1水平。结果本研究共纳入患者76例，其中观察组31例，对照组45例。观察组患者 Kim-1水平显著高于对照组，差异有统计学意义（t ＝4．765，P ＜0．01）；观察组患者尿 NGAL 水平显著高于对照组，差异有统计学意义（t ＝3．157，P ＜0．01）。Pearson 相关性检验显示，观察组患者 NGAL 水平与 Kim-1水平呈现显著正相关，差异有统计学意义（r ＝0．675，P ＜0．01）。ROC 曲线分析显示，当 Kim-1取值为4．71μg／L 时，对比剂肾病发生的预测敏感性为83．87％，特异性为84．44％，优于 NGAL。结论 Kim-1可用以辅助预测冠状动脉造影术后对比剂肾病的发生。%Objective To analyze the predictive value of kidney injury factor 1 (Kim-1 )in contrast-induced nephropathy after coronary arteriography.Methods Clinical data of patients received coronary arteriography in our hos-pital from 2010 to 2016 were analyzed.Patients were divided into two groups by whether patients had contrast-induced nephropathy (CIN)after coronary arteriography,including observation group (CIN)and control group (no CIN).Re-sults A total of 76 patients were collected in this study,31 cases were in observation group while 45 in control group. The Kim-1 and neutrophil gelatinase-associated lipocalin (NGAL)in observation group were significant higher than those in control group (P <0.05).Correlation analysis showed that Kim-1 was correlated positively and significantly with NGAL (r =0.675,P <0.01).ROC analysis showed that the value of Kim-1 was 4.71 μg/L,the sensitivity and specificity of prediction of CIN after coronary arteriography was 83.87%,84.44% respectively.Conclusion Kim-1 can be used as a predictive index of CIN after coronary arteriography.
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