Objective To explore the relationship between prehypertension and hsCRP and IL -6 in xinjiang kazakhs population and its clinical signifcance .Methods A total of 396 kazahs from physical-examination in 2011 were chosen and divided into the normal group ( n=124 ) ,prehypertension group ( n=144 ) and hypertension group (n=128).The levels of serum hsCRP,IL-6,total cholesterol (TC),triglyceride (TG),high-density lipoprotein cho-lesterol ( HDL-C) ,low-density lipoprotein cholesterol ( LDL-C) ,and fasting plasma glucose ( FBG) were detected in all the participants.Results There were significant difference in the levels of serum TC ,TG,LDL-C,HDL-C,FBG, systolic blood pressure (SBP) and diastolic blood pressure (DBP) among three groups ( all P<0.01).The levels of serum hsCRP and IL-6 were higher in the prehypertension group than those in the normal group (P<0.01),and low-er than those in the hypertension group (P <0.01).The result of multiple linear stepwise regression showed that hsCRP and IL-6 were correlated to SBP and DBP independently (P<0.001).Conclusion The people with prehy-pertension have higher levels of serum hsCRP and IL-6 in xinjiang kazakhs population ,which may be involved in the development of prehypertension .%目的探讨新疆哈萨克族人群正常高值血压与血清超敏C反应蛋白（hsCRP）、白细胞介素6（IL-6）水平的关系及临床意义。方法入选2011年门诊体检的新疆哈萨克族人群396例，按照血压水平分为血压正常组（n＝124）、正常高值血压组（n＝144）、高血压组（n＝128）三组，采用酶联免疫吸附试验法检测受试者血清hsCRP、IL-6浓度及其外周血三酰甘油、总胆固醇、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、空腹血糖水平，比较3组间各指标的差异。结果正常血压组、正常高值血压组和高血压组三组间三酰甘油、总胆固醇、HDL-C、空腹血糖、收缩压、舒张压差异均有统计学意义（均P＜0．01）；正常高值血压组血清hsCRP和IL-6水平均高于正常血压组［hsCRP：（0．8±0．3）比（0．4±0．2）mg/L；IL-6：（0．3±0．2）比（0．2±0．1）μg/L，均P＜0．01］，同时低于高血压组［hsCRP：（0．8±0．3）比（1．0±0．3）mg/L；IL-6：（0．3±0．2）比（0．4±0．2）μg/L，均P＜0．01］；血清hsCRP和IL-6与收缩压，舒张压独立相关（均P＜0．01）。结论新疆哈萨克族正常高值血压人群体内已存在炎性反应，hsCRP和IL-6可能参与了新疆哈萨克族正常高值血压的发生发展。
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