目的 探讨中老年男性下丘脑-垂体-肾上腺轴激素水平改变对生活质量的影响.方法 收集45~90岁中老年男性150例,分为45~59岁中年组(50例),60~79岁老年组(50例),80~90岁高龄老年组(50例).各组分别测定血清促肾上腺激素皮质激素(ACTH)、皮质醇、脱氢表雄酮(DHEA)水平,同时使用健康状况问卷(SF-36)对各组进行生活质量评估.结果 年龄与血清DHEA水平呈负相关(r=-0.505,P<0.05),与血清ACTH、皮质醇水平呈正相关(r=0.248,r=0.327,均P<0.05).血清DHEA水平与SF-36健康量表各纬度评分呈正相关(P<0.05).结论 随着年龄的增长下丘脑-垂体-肾上腺轴激素水平发生改变,DHEA水平降低影响中老年男性的健康状态.%Objective To invesligale change in the aclivily of hypolhalamic-piluilary-adrenal axis in fluence the quality of life in the middle-aged and the elder males. Methods 150 middle-aged and elder men from 45 to 95 years old were divided into three groups according lo their age. The levels of serum, adrenocorlicolropic hormone cortical hormone(ACTH) , cortisol, dehydroepia-ndroslerone (DHEA) were measured, at the same lime using the Heallh Slalus Queslionnaire(SF-36) the quality of life of each group was assessed. Results DHEA levels were negatively correlaled (r = — 0. 505, P <0. 05) , lo age and the serum of ACTH, corlisol levels are positively correlated lo age( r = 0.248, r =0. 327, P<0. 05) . The SF-36 Health Questionnaire latitude score are positively correlaled(P<0. 05) to serum DHEA. Conclusion The activity of hypolhalamic-piluilary-adrenal axis changes with age. This change affects the health status of the middle-aged and elderly men.
展开▼
