Objective:To evaluate the correlation between changes in brain metabolism and the reduction in small arteries in patients with hypertension.Methods:Fifty patients with hypertension and fifty volunteers without hypertension were enrolled.The two groups underwent 3T 3D time of flight MR angiography (MRA) and Single voxel proton MR spectroscopic (MRS).The numbers of lenticulostriate arteries (LSAs) and the ratios of Nacetylaspartate to creatine (NAA/Cr), myoinositol to creatine (MI/Cr), and choline to creatine (Cho/Cr) on the basal ganglia regions were calculated.Results:The average total number of LSA stems on both sides in patients with hypertension and volunteers without hypertension was 5.12±0.98 and 6.10±0.95, respectively (P<0.000 1).The NAA/Cr ratio decreased according to a reduction in the number of LSAs in the hypertension group, which was significantly reduced when the number of LSAs was 3 or fewer.Conclusions:Hypertension can lead to a statistically significant reduction in NAA/Cr ratio on the basal ganglia regions when the number of LSAs decreases to a certain extent.%目的:探讨高血压患者脑微小血管数量减少与局部脑代谢改变的关系.方法:将50例高血压患者和50例健康志愿者纳入本研究.所有研究对象均行三维时间飞跃法磁共振血管成像和磁共振波谱成像扫描,对所有图像进行后处理后计算豆纹动脉数量和基底节区脑代谢物NAA/Cr、Cho/Cr、MI/Cr比值.结果:高血压组和健康志愿者组双侧豆纹动脉数量分别为5.12±0.98、6.10±0.95,差异有统计学意义(P<0.000 1).高血压组患者NAA/Cr比值的降低与豆纹动脉数量减少具有一定相关性,单侧豆纹动脉数量≤3时,NAA/Cr比值下降得更显著.结论:高血压患者豆纹动脉数量减少至一定范围可引起基底节区脑代谢物NAA/Cr比值的降低.
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