Objective:To explore whether the application of magnesium could affect the postoperative analgesia in pediatric appendectomy . Methods: This was a randomized , double‐blind , placebo‐controlled study . Forty patients undergoing appendectomy ,aged from 8 to15 years ,were assigned to two groups .Patients from M group received magnesium 50 mg/kg before surgery ,while patients from P group received 0 .9% sodium chloride solution .No analgesic was applied during the operation .The postoperative pain score ,sedation score ,analgesic consumption and incidence rate of adverse reaction were compared between the two groups .Results:There were significant differences between the two groups regarding pain score , analgesia consumption and part of sedation score .There was no significant difference between the two groups regarding the adverse reactions such as respiratory depression , nausea , vomit , bradycardia and hypotension . Conclusions:Preoperative application of magnesium 50 mg/kg could significantly reduce the postoperative pain and opioids consumption for children undergoing appendectomy .Meanwhile , the incidence rates of complications such as bradycardia , hypotension , respiratory depression ,nausea ,vomit and skin itch would not change .%目的：探讨硫酸镁是否对小儿阑尾炎手术术后镇痛有影响。方法：采取随机、对照、双盲试验方法，将40名年龄为8～15岁的拟行阑尾切除术的患儿分为两组，每组20例。在术前给予M组硫酸镁50 mg／kg ，P组则接受相同容量的0．9为氯化钠液。手术中不使用任何镇痛药物。比较两组患者术后疼痛评分、镇静以及镇痛药物的消耗量和不良反应的发生率。结果：两组患者在术后镇痛评分以及其他镇痛药物的消耗量方面，差异有统计学意义（P＜0．05）；部分镇静评分差异有统计学意义（P＜0．05）。两组患者在呼吸抑制、恶心呕吐、心动过缓和低血压等不良反应上差异则无统计学意义。结论：对于行阑尾切除术的小儿，术前使用50 mg／kg硫酸镁可明显降低术后疼痛、减少阿片类药物的使用，且不会增加不良反应的发生率。
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