Objective: To investigate the infection of Chlamydia pneumonia(Cpn) in stroke patients and its relationship with risk factors of stroke. Methods:In this case-control study,120 patients with stroke and 60 healthy controls were tested scrologi-cally for specific Cpn-IgM, Cpn-IgA and Cpn-IgG by enzyme-linked immunoadsorbent assay (KLKSA). Moreover, cholesterol (TO, triacylglyccridc(TG) , high density lipoprotcin( HDL) and low density lipoprotcin(LDL) were also detected. According to pathogencsis and imaging findings of stroke, 120 cases were divided into four groups: cerebral infarction groupCn = 48), transient ischemic attack(TIA) group Cn - 14), cerebral cardiocmbolism groupCn - 29) and hcmatcnccphalon groupCn -29). Results: There were significant differences between cases and controls in TC, TG, HDL, LDL, Cpn-IgA and Cpn-IgG scropos-itivity. Logistic stepwisc regression analysis showed that Cpn-IgA and Cpn-IgG scropositivity were independently associated with atherosclerosis stroke (including cerebral infarction and TIA) , but not with cardiocmbolic or hcmatcnccphalon subtypes. 180 people in this study were divided into Cpn-IgA scropositivity groupCn = 124) and Cpn-IgA scroncgativity groupCn = 56). The levels of scrum TC, TG, LDL in Cpn-IgA scropositivity group were significantly higher than those in Cpn-IgA scroncgativity group. Conclusions: Scrologic positivity of Cpn-IgA and Cpn-IgG is independently related to atherosclerosis stroke. The mechanism is likely to be associated with dyslipidcmia.%目的:探讨肺炎衣原体(Chlamydia pneumonia,Cpn)感染与卒中的关系.方法:用酶联免疫吸附法(ELESA)测定卒中患者(研究组)120例和健康体检者(对照组)60例血清中Cpn抗体(IgM、IgA、IgG),同时测定其血清总胆固醇(cholesterol,TC)、三酰甘油(triacylglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL)、低密度脂蛋白(low density lipoprotein,LDL)水平.根据卒中的发病机制和影像学检查将研究组分为4个亚组:脑血栓形成组(48例)、短暂性脑缺血发作(transient ischemic attack,TIA)组(14例)、心源性脑栓塞组(29例)、脑出血组(29例).分析Cpn-IgM、Cpn-IgA、Cpn-IgG与卒中各亚组的相关性以及Cpn-IgA与血脂的关系.结果:研究组和对照组的性别、年龄、糖尿病史、吸烟史、高血压史差异均无统计学意义,两组间的TC、TG、LDL、HDL水平有显著差异(P<0.05);研究组各亚组中Cpn-IgA、Cpn-IgG阳性与脑血栓形成、TIA呈独立相关,与心源性脑栓塞、脑出血无显著相关;Cpn-IgA阳性组(124例)与阴性组(56例)的TC、TG、LDL差异有统计学意义(P<0.001).结论:Cpn慢性反复感染可能是动脉粥样硬化性脑血管病的独立危险因素,其致病机制可能与血脂代谢异常有关.
展开▼
