AIM：To investige the treatment ef fect s and mechanism of hyperbaric oxygenation(HBO) to helicobacter pylori(Hp) in den tal plaque. METHODS：120 patients of second degree period ontitis (Hp-PCR positive) were divided into 4 groups: The changes of periodontal measur ements compared at 1,3,6 months post treatment. RESULTS： T he Hp positive rate showed significant difference between 4 groups and they were 96.7%, 80.0%, 73.3%, 0 after 6 mouths. The effect of treatment of group D was the best (P<0.01), better than those of other groups(P<0.05). CONCLUSION：HBO may kill Hp in dental plaque effectively when patients received treatment of oral prophylax is and Triple therapy.%目的：寻找一种较为理想的根除口腔幽门 螺杆菌(Hp)的方法。方法：将120例口腔牙菌斑Hp-PCR检测阳性的Ⅱ 度牙周炎患者分为A、B、C、D 4组，治疗1、3、6月后分别对所有患者牙周参数和龈下 菌斑进行Hp-PCR检测并比较检测结果。结果：4组Hp阳性率分别为96 .7%、80.0%、73.3%和0，有显著性差异(P<0.05)，其中以D组最低(P<0.01)；临床 牙周参数变化亦有显著差别(P<0.05)。结论：高压氧对口腔Hp 有明显抑制或杀灭作用，高压氧配合治疗，有助于口腔 Hp 的根除和与Hp有关的疾病的治疗。
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