Objective To invesligalion ihe correlation and regression relalionship belween ihe differenl negalive pressures spulum aspiralion and ihe loss volume of pulmonary recruilmenl in palienls wilh ARDS, for clinical seleclion ihe proper of recruilmenl slralegy lo provide reference. Methods In prospective and self controlled study, Iwenly - eighl palienls fulfilling criteria for acule respiralory distress syndrome were eligible. They were randomly assigned lo be endotr - acheal suclioning with pressure 150, 160, 170, 180, 190 or 200 mm Hg, ihen standard procedure endolracheal suclioning. Record ihe volume lung re - expansion before and after differenl negative spulum aspiration. Results There were significant positive correlation between ihe negative pressure spulum aspiration and ihe loss volume of pulmonary ( r = 0. 513 , P = 0. 000) . The higher pressure of sputum aspiralion induced the more loss volume of pulmonary recruilmenl. Conclusion The differenl pressure of sputum aspiralion can cause the change of lung recruiled volume. On ARDS patienls the lung recruilmenl afler sputum aspiralion should refer lo ihe missing values caused by the negalive pressure sputum aspiralion, lo prevenl the excessive or inadequate venlilalion induced lung injury.%目的 探讨急性呼吸窘迫综合征(ARDS)患者不同吸痰负压与肺复张容积缺失值的相关与回归关系.方法 前瞻性自身对照分析ARDS患者28例,分别使用150、160、170、180、190及200 mm Hg的负压进行开放式吸痰,记录不同负压吸痰前后肺容积的变化.结果 吸痰负压与缺失肺复张容积之间存在显著的正相关关系(r=0.513,P=0.000),即吸痰负压越大,其引起的肺容积缺失越多,差异有统计学意义(P<0.001).结论 不同的吸痰负压能够引起肺复张容积明显的改变,对ARDS患者进行吸痰后的肺复张,应参考吸痰负压所引起的相应肺容积缺失值,以防止过度或者不足通气引起ARDS患者的肺损伤.
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