Objective To evaluate the clinical value of elevated MPV in patients with colon carcinoma.Methods A total of 146 colon carcinoma patients as well as 154 age and sex matched healthy cases were selected during September 2014 to September 2016 from Hanyang Hospital and Renmin Hospital of Wuhan University.MPV was compared among the two groups pre and after surgery.MPV levels were calculated, and MPV was analyzed according to different clinic pathological features in colon carcinoma patients.Besides, a ROC curve was applied to analyze the best cut off value of MPV for diagnosing carcinoma of colon.Results The MPV(t=9.446,P<0.01) and PLT(t=2.792,P=0.006)were higher and the Hb(t=2.990,P=0.003)was lower in colon cancer group than those in the controls.The patients who had experienced distant metastasis(t=2.009,P=0.046)and those who were in stage III to IV(t=2.438,P=0.014)had a high level of MPV.Correlation analysis revealed that MPV was positively correlated with organ metastasis and III to IV stage tumor (r=0.561,r=0.599,P=0.042,P=0.016, respectively), but there was no correlation between MPV and depth of infiltration, degree of differentiation and lymph node metastasis (r=0.060,r=-0.116,r=0.115,P>0.05).Both MPV (t=3.987,P<0.01) and PLT (t=1.696,P=0.033)were decreased after surgery compared to that in pre-operative.ROC analysis suggested that the best cutoff value of MPV was 11.95 fl to diagnose cancer of colon (AUC=0.779,95%CI0.727-0.832,sensitivity 82.2%, specificity 61.1%).Conclusion The increase of MPV level in patients with colon cancer has important clinical significance.MPV may be an important marker for the diagnosis and prognosis of colon cancer.%目的 分析结肠癌患者平均血小板容积(MPV)升高的临床意义.方法 选择2014年9月-2016年9月在武汉市汉阳医院及武汉大学人民医院消化内科首次诊断为结肠癌患者146例作为研究对象,并以同期医院健康体检者154例作为健康对照组,比较2组患者MPV的差异及结肠癌患者术前术后MPV的差异;同时分析MPV与结肠癌不同病理特征的相关性,并利用ROC曲线分析MPV诊断结肠癌的临床价值.结果 结肠癌组MPV、PLT明显高于健康对照组(t=9.446、2.792,P<0.01),而Hb却低于健康对照组(t=-2.990,P<0.01).术后MPV(11.3±1.0)fl、PLT(194.8±61.0)×109/L均低于术前(11.8±1.0)fl、(204.5±57.7)×109/L,差异有统计学意义(t=3.987、1.696,P=0.001、0.033).有脏器转移者MPV水平高于无脏器转移者,Ⅲ~Ⅳ期高于Ⅰ~Ⅱ期患者(t=2.009、2.438,P<0.05).MPV水平与脏器转移、TNMⅢ~Ⅳ期呈正相关(r=0.561、0.599,P<0.05),而与肿瘤是否侵及肌层、分化程度及淋巴结转移情况无明显相关(r=0.060、-0.116、0.115,P>0.05).MPV预测结肠癌的ROC曲线下面积为0.779,95%CI0.727~0.832,最佳截断值为11.95 fl,敏感度和特异度分别为82.2%和61.1%.结论 结肠癌患者MPV水平升高具有重要的临床意义,MPV可能是结肠癌诊断及预后判断的一个重要标志物.
展开▼
